B 细胞受体特异性在慢性淋巴细胞白血病中的意义：生物学和临床意义。
The Significance of B-cell Receptor Stereotypy in Chronic Lymphocytic Leukemia: Biological and Clinical Implications.
机构信息
Institute of Applied Biosciences, Centre for Research and Technology Hellas, 6th km Charilaou - Thermis, 57001 Thermi, Thessaloniki, Greece; Department of Genetics and Molecular Biology, Faculty of Biology, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
Institute of Applied Biosciences, Centre for Research and Technology Hellas, 6th km Charilaou - Thermis, 57001 Thermi, Thessaloniki, Greece; Laboratory of Biological Chemistry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
出版信息
Hematol Oncol Clin North Am. 2021 Aug;35(4):687-702. doi: 10.1016/j.hoc.2021.03.003. Epub 2021 May 26.
The finding that (quasi)identical, stereotyped B-cell receptor (BcR) immunoglobulins IGs) are expressed in a significant fraction of chronic lymphocytic leukemia (CLL) highlighted the importance of antigen selection in disease pathogenesis. Subsets of patients sharing the same stereotyped BcR IG display consistent biological features and, at least for certain subsets, clinical presentation and outcome, including the response to particular treatment. On these grounds, BcR IG stereotypy emerges as a useful tool for dissecting the pronounced heterogeneity of CLL toward refining risk stratification and therapeutic management aligned with the principles of precision medicine.
研究发现，相当一部分慢性淋巴细胞白血病（CLL）中表达了（准）相同的、刻板的 B 细胞受体（BcR）免疫球蛋白（IGs），这凸显了抗原选择在疾病发病机制中的重要性。具有相同刻板 BcR IG 的患者亚群具有一致的生物学特征，至少对于某些亚群，包括对特定治疗的反应，其临床表现和结果也是一致的。基于这些原因，BcR IG 刻板性成为一种有用的工具，可以对 CLL 明显的异质性进行剖析，以完善风险分层和治疗管理，并与精准医学的原则保持一致。
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