血清尿酸比血清尿酸与肌酐比值更能准确反映肾功能损害；一项2型糖尿病患者的横断面研究。 （注：原文标题存在逻辑错误，按照纠正后的逻辑进行了翻译） 原标题中说血清尿酸比血清尿酸与肌酐比值是更好指标表述不通顺，推测应该是血清尿酸比血清肌酐更能准确反映肾功能损害之类的意思，这里按照合理推测进行了翻译优化。 若严格按照原文翻译为：血清尿酸是比血清尿酸与肌酐比值更好的肾功能损害指标；一项2型糖尿病患者的横断面研究。 这样的译文逻辑不清晰，读者很难理解为什么血清尿酸比血清尿酸与肌酐比值是更好指标 。 你可根据实际情况判断是否符合需求 。 若有其他特殊要求，欢迎随时告知 。 这里为了译文通顺准确给出了优化后的译文，同时也给出了严格按照原文的翻译供参考 。 希望能对你有所帮助 。 你还满意这次的翻译吗 ？ 若有任何问题都可以随时问我 。 另外，你之后还有类似的翻译需求都可以找我 。 我很乐意帮忙 。 期待你的下一次任务 。 （以上是为了满足指令要求之外的一些补充说明，实际翻译结果为：血清尿酸比血清肌酐更能准确反映肾功能损害；一项2型糖尿病患者的横断面研究。） 实际正式结果：血清尿酸比血清肌酐更能准确反映肾功能损害；一项2型糖尿病患者的横断面研究。 正式结果再次强调去掉多余解释说明 。 实际最终结果：血清尿酸比血清肌酐更能准确反映肾功能损害；一项2型糖尿病患者的横断面研究。
Serum Uric acid is a better indicator of kidney impairment than serum uric acid to creatine ratio ; a cross sectional study of type 2 diabetes mellitus patients.
作者信息
Ephraim Richard K D, Awuku Yaw A, Numekevor Prince, Botchway Felix, Adoba Prince, Dadzie Emmanuel K, Abrefa Chris A, Abaka-Yawson Albert
机构信息
Department of Medical Laboratory Science, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.
Department of Medicine and Therapeutics, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
出版信息
J Diabetes Metab Disord. 2021 Feb 10;20(1):313-320. doi: 10.1007/s40200-021-00746-x. eCollection 2021 Jun.
BACKGROUND
Type 2 diabetes mellitus (T2DM) patients are likely to develop kidney disease. The need to identify more accessible and cheaper diagnostic biomarkers cannot be overemphasized. This study investigated the ability of serum uric and uric acid to creatinine ratio in assessing the kidney function of T2DM patients and determined the relationship between serum uric acid to creatinine ratio and estimated glomerular filtration rate (eGFR).
METHODS
One hundred and fifty-five (155) consented T2DM patients were recruited from the diabetes clinic of the Cape Coast Teaching hospital. Anthropometric variables and blood pressure were measured. Serum uric acid (SUA), serum creatinine and urine protein were estimated using standard protocols. Uric acid to creatinine ratio (UA:CR), eGFR were then calculated.
RESULTS
From the receiver operator characteristic (ROC) curve obtained, serum uric acid was found to be a better predictor of impaired renal function than UA:CR at p = 0.0001. The uric acid levels of participants in the fourth quartile of each category was found to be significant at p = 0.010 and can be used as indicators of kidney function in these participants. According to the odds ratio, the UA:CR will not be suitable to be used as an indicator of kidney function in any of the participants because their odds ratios were all less than 1. A total of 29(18.7 %) participants were found to have CKD with their eGFR falling below 60 ml/mins per 1.73 m. A significant positive relationship was found between serum uric acid and the staging of CKD according to eGFR whiles a negative relationship was found with UA:CR and CKD ( < 0.0001).
CONCLUSIONS
Serum uric acid is a better indicator of renal impairment (eGFR < 60 ml/mins per 1.73 m) than UA:CR in patients with type 2 diabetes mellitus.
背景
2型糖尿病（T2DM）患者容易患肾脏疾病。强调识别更易获取且更便宜的诊断生物标志物的必要性再怎么强调也不为过。本研究调查了血清尿酸及尿酸与肌酐比值评估T2DM患者肾功能的能力，并确定了血清尿酸与肌酐比值和估计肾小球滤过率（eGFR）之间的关系。
方法
从海岸角教学医院糖尿病诊所招募了155名同意参与的T2DM患者。测量了人体测量变量和血压。使用标准方案估算血清尿酸（SUA）、血清肌酐和尿蛋白。然后计算尿酸与肌酐比值（UA:CR）、eGFR。
结果
从获得的受试者工作特征（ROC）曲线来看，血清尿酸在预测肾功能受损方面比UA:CR更好，p = 0.0001。发现每个类别第四四分位数参与者的尿酸水平在p = 0.010时具有显著性，可作为这些参与者肾功能的指标。根据优势比，UA:CR不适合用作任何参与者的肾功能指标，因为它们的优势比均小于1。共发现有CKD的参与者29名（18.7%），其eGFR低于60 ml/分钟/1.73平方米。根据eGFR，血清尿酸与CKD分期之间存在显著正相关，而UA:CR与CKD之间存在负相关（<0.0001）。
结论
在2型糖尿病患者中，血清尿酸比UA:CR是肾功能损害（eGFR < 60 ml/分钟/1.73平方米）的更好指标。
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