利用处方数据作为替代指标估算接受治疗的2型糖尿病的患病率和发病率：基于伊朗数据的逐步分析方法。
Estimating the prevalence and incidence of treated type 2 diabetes using prescription data as a proxy: A stepwise approach on Iranian data.
作者信息
Mirahmadizadeh Alireza, Banihashemi Sayed Aliakbar, Hashemi Mehdi, Amiri Sanaz, Basir Suzan, Heiran Alireza, Keshavarzian Omid
机构信息
Noncommunicable Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Kazeroun Branch, College of Medicine, Islamic Azad University, Kazeroun, Iran.
出版信息
Heliyon. 2021 Jun 9;7(6):e07260. doi: 10.1016/j.heliyon.2021.e07260. eCollection 2021 Jun.
AIMS
Type 2 diabetes is a serious health challenge, and large-scale studies on its prevalence in Iran are lacking. In pharmacoepidemiology, case-finding can be done by reviewing the prescription databases for specific drug(s) prescribed for a disease. We aimed to determine the prevalence and incidence of type 2 diabetes in Fars province, Iran, using prescription data and a stepwise approach to ascertain the results.
METHODS
A dataset of 3,113 insured individuals aged ≥35 years were selected. Their Prescription Data Centre records were reviewed for all drugs frequently used in controlling type 2 diabetes available in the Iranian pharmacopeia. Then we used a stepwise method for case-finding. In step one, each individual with a positive drug history for type 2 diabetes was labeled as an individual with diabetes. The next two steps were implemented for ascertainment of step one estimations.
RESULTS
Prevalence of type 2 diabetes based on prescription, internist opinion, and phone call verification in 2015 and 2016 was 9.3% and 10.3%, 8.5% and 9.8%, and 7.2% and 8.7%, respectively. An incidence of 1.9% was determined for 2016.
CONCLUSIONS
We obtained a realistic estimation of prevalence and incidence of treated type 2 diabetes, using prescription data which are large-scale, low cost, and real-time.
目的
2型糖尿病是一项严峻的健康挑战，而伊朗缺乏关于其患病率的大规模研究。在药物流行病学中，可以通过审查针对某种疾病所开特定药物的处方数据库来进行病例发现。我们旨在利用处方数据并采用逐步方法来确定伊朗法尔斯省2型糖尿病的患病率和发病率，以得出结果。
方法
选取了3113名年龄≥35岁的参保个体数据集。对他们在处方数据中心的记录进行审查，查看伊朗药典中所有常用于控制2型糖尿病的药物。然后我们采用逐步方法进行病例发现。第一步，将每位有2型糖尿病阳性用药史的个体标记为糖尿病患者。接下来的两步用于确定第一步估计值。
结果
基于处方、内科医生意见以及2015年和2016年电话核实得出的2型糖尿病患病率分别为9.3%和10.3%、8.5%和9.8%、7.2%和8.7%。2016年确定的发病率为1.9%。
结论
我们利用大规模、低成本且实时的处方数据，对接受治疗的2型糖尿病的患病率和发病率进行了实际估计。
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