Superior Canal Dehiscence 对肥沙鼠的声能吸收率、耳声发射和听力的影响。

The Impact of Superior Canal Dehiscence on Power Absorbance, Otoacoustic Emissions, and Hearing in Fat Sand Rats.

机构信息

Department of Communication Sciences & Disorders, University of Haifa, Haifa.

The Institute for Audiology & Clinical Neurophysiology, Schneider Children's Medical Center of Israel.

出版信息

Otol Neurotol. 2021 Aug 1;42(7):1104-1111. doi: 10.1097/MAO.0000000000003147.

DOI:10.1097/MAO.0000000000003147

PMID:34191786

Abstract

BACKGROUND

Superior Semicircular Canal Dehiscence (SSCD) may lead to vestibular and auditory impairments.

OBJECTIVE

To study the effects of power absorbance (PA), Distortion Product Otoacoustic emissions (DPOAE), and hearing thresholds in normal ears of fat sand rats, after a bullotomy, creation and patching.

METHODS

SSCD was performed unilaterally in eight normal hearing animals while the contra-lateral un-operated ear was used as a control. Measures included auditory brain stem responses thresholds for air and bone conduction stimuli, DPOAEs and PA at peak pressure.

RESULTS

The normal PA pattern of the animals grossly resembled that of human ears. A bullotomy generated specific, large and significant (p < 0.0001) changes in PA without altering hearing thresholds. SSCD significantly decreased PA at low (p < 0.02) and increased at high frequencies (p < 0.03), but on a smaller scale than the bullotomy. SSCD, induced a mean air-bone gaps of 24.3 for clicks, and 31.2 dB for 1 kHz TB. SSCD also increased the DPOAEs levels by mean of 10.1 dB SPL (p < 0.03). Patching the dehiscence, reversed partially the PA changes, the auditory threshold shifts, and the DPOAEs levels to pre-SSCD values.

CONCLUSIONS

SSCD affects both incoming and emitting sounds from the ear, probably due to its effect on cochlear impedance and stiffness of the middle and inner ear. The presence of DPOAEs and ABGs indicated a "third window" disease, i.e., SSCD. Due to similar PA patterns after bullotomy and SCCD, PA alone has limited diagnostic yield for patients with SCCD.

摘要

背景

上半规管裂可能导致前庭和听觉损伤。

目的

研究在进行臀肌切开术、造口术和修补术后，脂肪沙鼠正常耳的功率吸收率（PA）、畸变产物耳声发射（DPOAE）和听力阈值的变化。

方法

在 8 只正常听力动物的单侧耳进行 SSCD，而对侧未手术耳作为对照。测量包括空气和骨导刺激的听性脑干反应阈值、DPOAE 和峰值压力下的 PA。

结果

动物的正常 PA 模式与人类耳朵大致相似。臀肌切开术产生了特定的、大的且显著的（p<0.0001）PA 变化，而不改变听力阈值。SSCD 显著降低了低频（p<0.02）和高频（p<0.03）的 PA，但幅度小于臀肌切开术。SSCD 导致纯音听阈平均气骨间隙为 24.3 分，1 kHz 短纯音为 31.2 分。SSCD 还使 DPOAE 水平平均增加了 10.1 dB SPL（p<0.03）。修补裂孔部分逆转了 PA 变化、听觉阈值移位和 DPOAE 水平至 SSCD 前的值。