Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Diagn Microbiol Infect Dis. 2021 Oct;101(2):115447. doi: 10.1016/j.diagmicrobio.2021.115447. Epub 2021 Jun 4.
A 15-valent conjugate vaccine that provides protection against Streptococcus pneumoniae serotypes 22F and 33F is in development. Here we report on the prevalence, antimicrobial susceptibility, and clonal structure of these serotypes in Canada. From 2011 to 2018, the SAVE study collected 11,044 invasive S. pneumoniae isolates. Of these, 9.3% (1024/11,044) and 3.8% (416/11,044) were 22F and 33F, respectively. Serotype 22F isolates were susceptible to most antimicrobials tested except clarithromycin, where susceptibility significantly decreased over time (2011: 80.4%, 2018: 52.9%, P < 0.0001). Only 1.6% of serotype 22F isolates were multidrug-resistant (MDR), while 96% of typed strains were clonal cluster (CC) 433. Serotype 33F isolates demonstrated low susceptibility to clarithromycin and trimethoprim/sulfamethoxazole (22.4% and 24.6%, respectively) and 4.8% MDR. Most serotype 33F isolates were CC100, CC673 and CC717. CC100 prevalence increased significantly over time (2011: 50.0%, 2018: 84.8%, P < 0.006). Continued surveillance of these serotypes is crucial to identify further changes in prevalence, antimicrobial susceptibility, and clonal spread.
一种针对肺炎链球菌血清型 22F 和 33F 的 15 价结合疫苗正在研发中。在此，我们报告了这些血清型在加拿大的流行率、抗菌药物敏感性和克隆结构。2011 年至 2018 年期间，SAVE 研究收集了 11044 例侵袭性肺炎链球菌分离株。其中，22F 和 33F 分别占 9.3%（1024/11044）和 3.8%（416/11044）。除了克拉霉素之外，血清型 22F 分离株对大多数测试的抗菌药物均敏感，而其敏感性随着时间的推移显著下降（2011 年：80.4%，2018 年：52.9%，P < 0.0001）。只有 1.6%的血清型 22F 分离株为多药耐药（MDR），而 96%的定型菌株为克隆群（CC）433。血清型 33F 分离株对克拉霉素和复方磺胺甲噁唑的敏感性较低（分别为 22.4%和 24.6%），4.8%为 MDR。大多数血清型 33F 分离株为 CC100、CC673 和 CC717。CC100 的流行率随着时间的推移显著增加（2011 年：50.0%，2018 年：84.8%，P < 0.006）。对这些血清型的持续监测对于确定流行率、抗菌药物敏感性和克隆传播的进一步变化至关重要。
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