食蟹猴（猕猴）精原细胞经慢性γ射线照射后易位诱导的剂量反应关系。
Dose-response relationship for translocation induction in spermatogonia of the crab-eating monkey (Macaca fascicularis) by chronic gamma-ray-irradiation.
作者信息
Tobari I, Matsuda Y, Gu X H, Yamagiwa J, Utsugi T, Kitazume M, Okamoto M
机构信息
Division of Genetics, National Institute of Radiological Sciences, Chiba, Japan.
出版信息
Mutat Res. 1988 Sep;201(1):81-7. doi: 10.1016/0027-5107(88)90113-3.
The induction of reciprocal translocations in spermatogonia of the crab-eating monkey (Macaca fascicularis) by chronic gamma-irradiation (1.8 x 10(-5) Gy/min, about 0.024 Gy/22 h/day) was examined. The frequencies of translocation per cell were 0.15% at 0.3 Gy, 0.27% at 1.0 Gy and 0.33% at 1.5 Gy. The dose-response relationship for translocation yield was a linear one with a regression coefficient (b) of 0.16 x 10(-2). When the slope (b) of the regression line was compared with that at a high dose rate (0.25 Gy/min, b = 1.79 x 10(-2), it was clear that the induction rate of translocations after chronic gamma-irradiation was only about one-tenth of that after high-dose-rate irradiation. Thus, there was evidence for a pronounced dose-rate effect in the crab-eating monkey.
研究了慢性γ射线照射（1.8×10⁻⁵ Gy/分钟，约0.024 Gy/22小时/天）对食蟹猴（猕猴）精原细胞中相互易位的诱导作用。细胞的易位频率在0.3 Gy时为0.15%，1.0 Gy时为0.27%，1.5 Gy时为0.33%。易位产额的剂量-反应关系呈线性，回归系数（b）为0.16×10⁻²。当将回归线的斜率（b）与高剂量率（0.25 Gy/分钟，b = 1.79×10⁻²）下的斜率进行比较时，很明显慢性γ射线照射后易位的诱导率仅约为高剂量率照射后的十分之一。因此，有证据表明食蟹猴存在明显的剂量率效应。
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