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在 COVID-19 特定的三级护理重症监护病房中,严格遵循方案驱动管理的情况下,(2020 年 3 月至 2021 年 5 月)未发生毛霉菌病病例。

Absence of Case of Mucormycosis (March 2020-May 2021) under strict protocol driven management care in a COVID-19 specific tertiary care intensive care unit.

机构信息

Critical Care Medicine, Fortis Hospital Mulund, Mumbai, India.

Lilavati Hospital, Mumbai, India.

出版信息

Diabetes Metab Syndr. 2021 Jul-Aug;15(4):102169. doi: 10.1016/j.dsx.2021.06.006. Epub 2021 Jun 9.

Abstract

AIMS

With a sudden increase in cases of mucormycosis seen in Covid -19 patients, we conducted a retrospective analysis of all admitted patients in a tertiary care covid-19 hospital looking at incidence of mucormycosis.

METHODS

Intensive care unit daily rounds data stored in an electronic format was retrieved by one of the consultants, looking for incidence of mucormycosis, diabetes mellitus, adherence to protocol for steroid use, glycemic control and use of monoclonal antibodies. Also, patients follow up data base of post covid Outpatients Department was searched for cases of mucormycosis.

RESULTS

A total of 5248 patients were admitted between March 2020 to May 2021, of which 1027 were in ICU and 4221 in wards. Of the 1027 patients admitted in Intensive care unit, 915 received steroids and 417 had diabetes as existing co-morbidity. No case of mucormycosis was reported during the stay in the hospital and during immediate outpatient department follow up. The low dose steroids were administered as per state government protocol for treating COVID 19, a nurse driven strict glycemic control regime (blood glucose level was maintained between 140 and 180 mg/dl through the admission in ICU and was achieved consistently in 842 (82%) patients, followed along with minimal use of other immunomodulatory like monoclonal antibodies.

CONCLUSION

A strict adherence to protocol of low dose steroids coupled with strict glycemic control helped in eliminating the risk and incidence of mucormycosis in a tertiary care dedicated covid-19 hospital.

摘要

目的

由于 COVID-19 患者中曲霉菌病病例突然增加,我们对一家三级新冠病毒医院的所有住院患者进行了回顾性分析,以观察曲霉菌病的发病率。

方法

一位顾问检索了以电子格式存储的重症监护病房日常查房数据,寻找曲霉菌病、糖尿病、类固醇使用方案依从性、血糖控制和单克隆抗体使用的发病率。此外,还搜索了新冠病毒门诊患者的后续数据,以寻找曲霉菌病的病例。

结果

2020 年 3 月至 2021 年 5 月期间共收治 5248 例患者,其中 1027 例在 ICU,4221 例在病房。在 ICU 住院的 1027 名患者中,915 名患者接受了类固醇治疗,417 名患者患有糖尿病等合并症。在住院期间和随后的门诊随访期间均未报告曲霉菌病病例。低剂量类固醇是根据州政府治疗 COVID-19 的方案使用的,有一名护士严格控制血糖水平(血糖水平在 140 至 180mg/dl 之间,842 名(82%)患者在 ICU 住院期间保持了这一水平,并且在使用其他免疫调节剂如单克隆抗体方面也保持了最小用量。

结论

严格遵循低剂量类固醇方案和严格血糖控制有助于在一家三级新冠病毒专用医院消除曲霉菌病的风险和发病率。

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