Division of Nano Life Science in the Graduate School of Frontier Science Initiative, Kanazawa University, Kanazawa 920-1192, Japan.
WPI-Nano Life Science Institute, Kanazawa University, Kanazawa 920-1192, Japan.
Cells. 2021 Jun 7;10(6):1424. doi: 10.3390/cells10061424.
The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response. Viruses encode many factors that interact with the host nuclear transport receptors (NTRs) and the nucleoporins of the nuclear pore complex (NPC) to access the host nucleus. In this review, we discuss the viral factors and the host factors involved in the nuclear import and export of viral components. As nucleocytoplasmic shuttling is vital for the replication of many viruses, we also review several drugs that target the host nuclear transport machinery and discuss their feasibility for use in antiviral treatment.
宿主核质转运系统经常被病毒劫持，以完成其复制并抑制宿主免疫反应。病毒编码了许多与宿主核转运受体（NTR）和核孔复合体（NPC）核孔蛋白相互作用的因子，以进入宿主细胞核。在这篇综述中，我们讨论了参与病毒成分核输入和核输出的病毒因子和宿主因子。由于核质穿梭对许多病毒的复制至关重要，我们还回顾了几种靶向宿主核转运机制的药物，并讨论了它们在抗病毒治疗中的应用可行性。
Zotero 插件