Graduate School of Biotechnology and Food Science, Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya Street 29, 195251 Saint Petersburg, Russia.
Smorodintsev Research Institute of Influenza, Prof. Popov Street 15/17, 197376 Saint Petersburg, Russia.
Molecules. 2021 Jun 23;26(13):3836. doi: 10.3390/molecules26133836.
The increased complexity due to the emergence and rapid spread of new viral infections prompts researchers to search for potential antiviral and protective agents for mucous membranes among various natural objects, for example, plant raw materials, their individual components, as well as the products of their chemical modification. Due to their structure, resin acids are valuable raw materials of natural origin to synthesize various bioactive substances. Therefore, the purpose of this study was to confirm the possibility of using resin acid derivatives for the drug design. As a result, we studied the cytotoxicity and biological activity of resin acid derivatives. It was shown that a slight decrease in the viral load in the supernatants was observed upon stimulation of cells () compared with the control. When using PASS-online modeling (Prediction of Activity Spectra for Substances), the prediction of the biological activity spectrum showed that compound () is capable of exhibiting antiviral activity against the influenza virus. The use of the SWISS-ADME webserver to reveal the drug-like properties of compounds did not directly indicate the presence of antiviral activity. These results indicate the potential of resin acid derivatives as a starting point for extensive research in the study of biological activity.
由于新的病毒感染的出现和迅速传播而导致的复杂性促使研究人员在各种天然物体中寻找潜在的抗病毒和保护粘膜的药物，例如植物原料、其单个成分以及其化学修饰产物。由于其结构，树脂酸是有价值的天然原料，可用于合成各种生物活性物质。因此，本研究的目的是确认使用树脂酸衍生物进行药物设计的可能性。结果，我们研究了树脂酸衍生物的细胞毒性和生物活性。结果表明，与对照组相比，细胞刺激时观察到上清液中的病毒载量略有下降（）。当使用 PASS-online 建模（物质活性谱预测）时，生物活性谱的预测表明化合物（）能够表现出抗流感病毒的抗病毒活性。使用 SWISS-ADME 网络服务器来揭示化合物的类药性并没有直接表明存在抗病毒活性。这些结果表明树脂酸衍生物具有作为广泛研究生物活性的起点的潜力。
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