不同他汀类药物处理的MiaPaCa-2胰腺癌细胞转录组图谱的比较
Comparison of Transcriptomic Profiles of MiaPaCa-2 Pancreatic Cancer Cells Treated with Different Statins.
作者信息
Rimpelová Silvie, Kolář Michal, Strnad Hynek, Ruml Tomáš, Vítek Libor, Gbelcová Helena
机构信息
Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague, Czech Republic.
Laboratory of Genomics and Bioinformatics, Institute of Molecular Genetics, Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic.
出版信息
Molecules. 2021 Jun 9;26(12):3528. doi: 10.3390/molecules26123528.
Statins have been widely used for the treatment of hypercholesterolemia due to their ability to inhibit HMG-CoA reductase, the rate-limiting enzyme of de novo cholesterol synthesis, via the so-called mevalonate pathway. However, their inhibitory action also causes depletion of downstream intermediates of the pathway, resulting in the pleiotropic effects of statins, including the beneficial impact in the treatment of cancer. In our study, we compared the effect of all eight existing statins on the expression of genes, the products of which are implicated in cancer inhibition and suggested the molecular mechanisms of their action in epigenetic and posttranslational regulation, and in cell-cycle arrest, death, migration, or invasion of the cancer cells.
他汀类药物因其能够通过所谓的甲羟戊酸途径抑制HMG-CoA还原酶（从头合成胆固醇的限速酶），而被广泛用于治疗高胆固醇血症。然而，它们的抑制作用也会导致该途径下游中间体的消耗，从而产生他汀类药物的多效性作用，包括对癌症治疗的有益影响。在我们的研究中，我们比较了所有八种现有他汀类药物对基因表达的影响，这些基因的产物与癌症抑制有关，并提出了它们在表观遗传和翻译后调控以及癌细胞的细胞周期停滞、死亡、迁移或侵袭中的作用分子机制。
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