低水平的miR-1231表达预示非小细胞肺癌预后不良，并加速细胞增殖、迁移和侵袭。
Low miR-1231 expression predicts poor prognosis in non-small-cell lung cancer and accelerates cell proliferation, migration and invasion.
作者信息
Zhu Lina, Zhang Ke, Zhang Chu, Yu Hui, Zhu Lirong
机构信息
Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu, 213003, China.
Department of Cardiothoracic Surgery, Changzhou no. 2 People's Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu, 213000, China.
出版信息
Biomark Med. 2021 Aug;15(11):831-840. doi: 10.2217/bmm-2020-0313. Epub 2021 Jul 5.
miRNAs have been found to be involved in the tumor progression. This study aimed to assess the prognostic significance and biological function of miRNA-1231 (miR-1231) in non-small-cell lung cancer (NSCLC). Expression of miR-1231 was measured by using quantitative real-time PCR. The prognosis value of miR-1231 was evaluated by Kaplan-Meier survival curves and Cox regression analysis. The biological function of miR-1231 was further studied. Expression of miR-1231 in NSCLC patients and NSCLC cell lines were decreased. MiR-1231 was an independent prognostic biomarker. Overexpression of miR-1231 inhibited NSCLC cell proliferation, migration and invasion. Downregulated expression of miR-1231 serves as a prognostic biomarker of NSCLC and may be a potential therapeutic target.
已发现微小RNA（miRNA）参与肿瘤进展。本研究旨在评估miRNA-1231（miR-1231）在非小细胞肺癌（NSCLC）中的预后意义和生物学功能。采用定量实时聚合酶链反应检测miR-1231的表达。通过Kaplan-Meier生存曲线和Cox回归分析评估miR-1231的预后价值。进一步研究miR-1231的生物学功能。NSCLC患者和NSCLC细胞系中miR-1231的表达降低。miR-1231是一种独立的预后生物标志物。miR-1231的过表达抑制NSCLC细胞的增殖、迁移和侵袭。miR-1231表达下调可作为NSCLC的预后生物标志物，可能是一个潜在的治疗靶点。
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