School of Life Science, Liaoning University, Shenyang, 110036, China.
Research Center for Computer Simulating and Information Processing of Bio-Macromolecules of Shenyang, Liaoning University, Shenyang, 110036, China.
Interdiscip Sci. 2021 Sep;13(3):535-545. doi: 10.1007/s12539-021-00458-z. Epub 2021 Jul 7.
LncRNA-miRNA interactions contribute to the regulation of therapeutic targets and diagnostic biomarkers in multifarious human diseases. However, it remains difficult to experimentally identify lncRNA-miRNA associations at large scale, and computational prediction methods are limited. In this study, we developed a network distance analysis model for lncRNA-miRNA association prediction (NDALMA). Similarity networks for lncRNAs and miRNAs were calculated and integrated with Gaussian interaction profile (GIP) kernel similarity. Then, network distance analysis was applied to the integrated similarity networks, and final scores were obtained after confidence calculation and score conversion. Our model obtained satisfactory results in fivefold cross validation, achieving an AUC of 0.8810 and an AUPR of 0.8315. Moreover, NDALMA showed superior prediction performance over several other network algorithms, and we tested the suitability and flexibility of the model by comparing different types of similarity. In addition, case studies of the relationships between lncRNAs and miRNAs were conducted, which verified the reliability of our method in predicting lncRNA-miRNA associations. The datasets and source code used in this study are available at https://github.com/Liu-Lab-Lnu/NDALMA .
LncRNA-miRNA 相互作用有助于调节多种人类疾病中的治疗靶点和诊断生物标志物。然而,从实验上大规模识别 lncRNA-miRNA 关联仍然很困难,计算预测方法也受到限制。在这项研究中,我们开发了一种用于 lncRNA-miRNA 关联预测的网络距离分析模型 (NDALMA)。计算了 lncRNA 和 miRNA 的相似性网络,并与高斯相互作用谱 (GIP) 核相似性进行了整合。然后,对整合的相似性网络进行网络距离分析,并在置信度计算和分数转换后获得最终分数。我们的模型在五重交叉验证中取得了令人满意的结果,AUC 为 0.8810,AUPR 为 0.8315。此外,NDALMA 显示出优于其他几种网络算法的预测性能,我们通过比较不同类型的相似性来测试模型的适用性和灵活性。此外,还进行了 lncRNA 和 miRNA 之间关系的案例研究,验证了我们方法在预测 lncRNA-miRNA 关联中的可靠性。本研究中使用的数据集和源代码可在 https://github.com/Liu-Lab-Lnu/NDALMA 上获得。