早发型胎儿生长受限孕妇的多普勒异常与围产结局。
Doppler abnormalities and perinatal outcomes in pregnant women with early-onset fetal growth restriction.
机构信息
Maternity School Assis Chateaubriand, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
Medicine Course, University of Fortaleza (UNIFOR), Fortaleza, CE, Brazil.
出版信息
J Matern Fetal Neonatal Med. 2022 Dec;35(25):7276-7279. doi: 10.1080/14767058.2021.1946786. Epub 2021 Jul 7.
OBJECTIVE
To compare Doppler alterations and perinatal outcomes in pregnant women who evolved with early- and late-onset fetal growth restriction (FGR).
METHODS
A retrospective, observational cohort study with pregnant women who evolved with FGR treated between January 2018 and April 2019, in which all live births from singleton pregnancies, over 24 weeks, with FGR ultrasound diagnosis and under 2700 g weight were included in the study.
RESULTS
Pregnancies with early-onset FGR were more associated with hypertensive disorders ( = .00) and placental vascular insufficiency, resulting in a high degree of umbilical artery Doppler involvement ( = .00) in a short period of pregnancy and higher rates of adverse perinatal outcomes ( = .00). The time of prenatal follow-up of early- and late-onset FGR cases was similar, but the degree of prematurity of the former made the evolution more unfavorable.
CONCLUSION
Early-onset FGR had a lower prevalence but was associated with higher maternal and fetal morbidity and mortality than late-onset FGR.
目的
比较早发型和晚发型胎儿生长受限（FGR）孕妇的多普勒改变和围产结局。
方法
这是一项回顾性、观察性队列研究，纳入了 2018 年 1 月至 2019 年 4 月期间治疗的 FGR 孕妇，所有单胎妊娠、超声诊断为 FGR 且体重低于 2700 克的 24 周以上孕妇均纳入研究。
结果
早发型 FGR 更常与高血压疾病（=0.00）和胎盘血管功能不全相关，导致妊娠早期出现严重的脐动脉多普勒异常（=0.00），且不良围产结局发生率更高（=0.00）。早发型和晚发型 FGR 病例的产前随访时间相似，但前者的早产程度使病情发展更不利。
结论
早发型 FGR 的发生率较低，但与晚发型 FGR 相比，其母婴发病率和死亡率更高。
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