脐带红细胞生成素与铁调素呈负相关，但不能捕捉到携带单胎的青少年和携带多胎的女性所生新生儿铁状态的最大变异性。
Umbilical Cord Erythroferrone Is Inversely Associated with Hepcidin, but Does Not Capture the Most Variability in Iron Status of Neonates Born to Teens Carrying Singletons and Women Carrying Multiples.
机构信息
Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
Division of Neonatology, Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY, USA.
出版信息
J Nutr. 2021 Sep 4;151(9):2590-2600. doi: 10.1093/jn/nxab156.
BACKGROUND
The developing fetus requires adequate iron and produces its own hormones to regulate this process. Erythroferrone (ERFE) is a recently identified iron regulatory hormone, and normative data on ERFE concentrations and relations between iron status and other iron regulatory hormones at birth are needed.
OBJECTIVES
The objective of this study was to characterize cord ERFE concentrations at birth and assess interrelations between ERFE, iron regulatory hormones, and iron status biomarkers in 2 cohorts of newborns at higher risk of neonatal anemia.
METHODS
Umbilical cord ERFE concentrations were measured in extant serum samples collected from neonates born to women carrying multiples (age: 21-43 y; n = 127) or teens (age: 14-19 y; n = 164). Relations between cord blood ERFE and other markers of iron status or erythropoiesis in cord blood were assessed by linear regression and mediation analysis.
RESULTS
Cord ERFE was detectable in all newborns delivered between 30 and 42 weeks of gestation, and mean concentration at birth was 0.73 ng/mL (95% CI: 0.63, 0.85 ng/mL). Cord ERFE was on average 0.25 ng/mL lower in newborns of black as opposed to white ancestry (P = 0.04). Cord ERFE was significantly associated with transferrin receptor (β: 1.17, P < 0.001), ferritin (β: -0.27, P < 0.01), and hemoglobin (Hb) (β: 0.04, P < 0.05). However, cord hepcidin and the hepcidin:erythropoietin (EPO) ratio captured the most variance in newborn iron and hematologic status (>25% of variance explained).
CONCLUSIONS
Neonates born to teens and women carrying multiples were able to produce ERFE in response to neonatal cord iron status and erythropoietic demand. ERFE, however, did not capture significant variance in newborn iron or Hb concentrations. In these newborns, cord hepcidin and the hepcidin:EPO ratio explained the most variance in iron status indicators at birth.
背景
发育中的胎儿需要足够的铁，并产生自身的激素来调节这一过程。红细胞生成素（erythroferrone，ERFE）是一种新发现的铁调节激素，需要对其在出生时的浓度以及与铁状态和其他铁调节激素之间的关系进行规范研究。
目的
本研究的目的是描述新生儿脐带血 ERFE 浓度，并评估在 2 组有新生儿贫血高风险的新生儿中 ERFE 与铁调节激素和铁状态生物标志物之间的相互关系。
方法
测量来自多胎妊娠（年龄：21-43 岁；n=127）或青少年（年龄：14-19 岁；n=164）孕妇分娩的新生儿脐带血中现存血清样本中的 ERFE 浓度。通过线性回归和中介分析评估脐带血 ERFE 与脐带血中其他铁状态或红细胞生成标志物之间的关系。
结果
在妊娠 30-42 周分娩的所有新生儿中均能检测到脐带 ERFE，出生时的平均浓度为 0.73ng/ml（95%CI：0.63，0.85ng/ml）。与白种人相比，黑人新生儿的 ERFE 平均低 0.25ng/ml（P=0.04）。脐带 ERFE 与转铁蛋白受体（β：1.17，P<0.001）、铁蛋白（β：-0.27，P<0.01）和血红蛋白（Hb）（β：0.04，P<0.05）显著相关。然而，脐带 hepcidin 和 hepcidin:erythropoietin（EPO）比值最能反映新生儿铁和血液学状态的变化（解释超过 25%的方差）。
结论
青少年产妇和多胎妊娠产妇的新生儿能够根据新生儿脐带铁状态和红细胞生成需求产生 ERFE。然而，ERFE 并没有捕捉到新生儿铁或 Hb 浓度的显著差异。在这些新生儿中，脐带 hepcidin 和 hepcidin:EPO 比值最能解释出生时铁状态指标的最大变化。
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