体外受精与胎盘绒毛加速成熟有关。
In vitro fertilization is associated with placental accelerated villous maturation.
作者信息
Londero Ambrogio P, Orsaria Maria, Parisi Nadia, Tassi Alice, Pittini Carla, Driul Lorenza, Mariuzzi Laura
机构信息
Clinic of Obstetrics and Gynecology, DAME, University of Udine, University Hospital of Udine Italy.
Institute of Pathology, DAME, University of Udine, University Hospital of Udine Italy.
出版信息
Int J Clin Exp Pathol. 2021 Jun 15;14(6):734-740. eCollection 2021.
OBJECTIVE
Accelerated placental maturation is regarded as a sign of vascular malperfusion and is often interpreted as a compensatory response by the placenta. In vitro embryo culture affects placental development. This study assessed placental maturation in spontaneous conceived and in vitro conceived pregnancies.
METHODS
Retrospective cohort study on a single center between 2014 and 2017. For this study, preterm placentas of singleton pregnancies between 24 and 36 weeks were considered. Routine placental examinations were retrospectively reviewed.
RESULTS
During the considered period, 423 placentas of singleton pregnancies were assessed. Three hundred ninety-six placentas were from spontaneous conception and 20 from in vitro fertilization and embryo transfer (IVF/ET). IVF/ET was significantly associated with accelerated villous maturation (AVM) and distal villous hypoplasia (DVH) (P<0.05).
CONCLUSIONS
Placental AVM and DVH were significantly associated with in vitro fertilization in singleton pregnancies. This result supports the hypothesis that AVM is a compensatory response by the placenta to improve its transport capacity in specific settings such as in vitro fertilization.
目的
胎盘加速成熟被视为血管灌注不良的标志，常被解释为胎盘的一种代偿反应。体外胚胎培养会影响胎盘发育。本研究评估了自然受孕和体外受孕妊娠中的胎盘成熟情况。
方法
对2014年至2017年间一个单一中心进行的回顾性队列研究。本研究纳入了24至36周单胎妊娠的早产胎盘。对常规胎盘检查进行回顾性分析。
结果
在研究期间，共评估了423例单胎妊娠的胎盘。其中396例胎盘来自自然受孕，20例来自体外受精-胚胎移植（IVF/ET）。IVF/ET与绒毛加速成熟（AVM）和远端绒毛发育不全（DVH）显著相关（P<0.05）。
结论
单胎妊娠中胎盘AVM和DVH与体外受精显著相关。这一结果支持了以下假设，即AVM是胎盘在特定情况下（如体外受精）为提高其转运能力而产生的一种代偿反应。
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