Queensland Alliance for Environmental Health Sciences, The University of Queensland, Australia; Wesley Hospital Brisbane, Queensland, Australia.
Queensland Alliance for Environmental Health Sciences, The University of Queensland, Australia.
Int J Hyg Environ Health. 2021 Jul;236:113801. doi: 10.1016/j.ijheh.2021.113801. Epub 2021 Jul 6.
Human biomonitoring of persistent organic pollutants (POPs) is typically based on serum analysis and for comparison and modelling purposes, data are often normalised to the lipid content of the serum. Such approach assumes a steady state of the compound between the serum lipids and for example lipid-rich adipose tissue. Few published data are available to assess the validity of this assumption. The aim of this study was to measure concentrations of POPs in both serum and adipose tissue samples from 32 volunteers and compare the lipid-normalised concentrations between serum and adipose tissue. For p,p'-DDE, PCB-138, PCB-153 and PCB-180, lipid-normalised adipose tissue concentrations were positively correlated to the respective serum concentrations but generally were more highly concentrated in adipose tissue. These results suggest that the investigated legacy POPs that were consistently found in paired samples may often not be in a steady state between the lipid compartments of the human body. Consequently, the analysis of serum lipids as a surrogate for adipose tissue exposure may more often than not underestimate total body burden of POPs. Further research is warranted to confirm the findings of this study.
人体中持久性有机污染物（POPs）的生物监测通常基于血清分析，为了进行比较和建模，数据通常会根据血清中的脂质含量进行标准化。这种方法假设化合物在血清脂质和例如富含脂质的脂肪组织之间处于稳定状态。目前只有少数已发表的数据可用于评估这种假设的有效性。本研究的目的是测量 32 名志愿者的血清和脂肪组织样本中的 POP 浓度，并比较血清和脂肪组织中脂质标准化的浓度。对于 p,p'-DDE、PCB-138、PCB-153 和 PCB-180，脂质标准化的脂肪组织浓度与相应的血清浓度呈正相关，但通常在脂肪组织中浓度更高。这些结果表明，在所研究的一致存在于配对样本中的遗留 POPs 可能通常不会在人体的脂质隔室之间处于稳定状态。因此，分析血清脂质作为脂肪组织暴露的替代物可能经常会低估 POP 的全身负担。需要进一步的研究来证实本研究的结果。
