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州级阿片类药物处方改革后腰椎减压手术后术后阿片类药物处方的变化。

The change in postoperative opioid prescribing after lumbar decompression surgery following state-level opioid prescribing reform.

作者信息

Winkelman Robert D, Kavanagh Michael D, Tanenbaum Joseph E, Pelle Dominic W, Benzel Edward C, Mroz Thomas E, Steinmetz Michael P

机构信息

1Center for Spine Health, Neurological Institute, and.

2Case Western Reserve University School of Medicine; and.

出版信息

J Neurosurg Spine. 2021 Jul 9;35(3):275-283. doi: 10.3171/2020.11.SPINE201046. Print 2021 Sep 1.

Abstract

OBJECTIVE

On August 31, 2017, the state of Ohio implemented legislation limiting the dosage and duration of opioid prescriptions. Despite the widespread adoption of such restrictions, few studies have investigated the effects of these reforms on opioid prescribing and patient outcomes. In the present study, the authors aimed to evaluate the effect of recent state-level reform on opioid prescribing, patient-reported outcomes (PROs), and postoperative emergency department (ED) visits and hospital readmissions after elective lumbar decompression surgery.

METHODS

This study was a retrospective cohort study of patients who underwent elective lumbar laminectomy for degenerative disease at one of 5 hospitals within a single health system in the years prior to and after the implementation of the statewide reform (September 1, 2016-August 31, 2018). Patients were classified according to the timing of their surgery relative to implementation of the prescribing reform: before reform (September 1, 2016-August 31, 2017) or after reform (September 1, 2017- August 31, 2018). The outcomes of interest included total outpatient opioids prescribed in the 90 days following discharge from surgery as measured in morphine-equivalent doses (MEDs), total number of opioid refill prescriptions written, patient-reported pain at the first postoperative outpatient visit as measured by the Numeric Pain Rating Scale, improvement in patient-reported health-related quality of life as measured by the Patient-Reported Outcomes Measurement Information System-Global Health (PROMIS-GH) questionnaire, and ED visits or hospital readmissions within 90 days of surgery.

RESULTS

A total of 1031 patients met the inclusion criteria for the study, with 469 and 562 in the before- and after-reform groups, respectively. After-reform patients received 26% (95% CI 19%-32%) fewer MEDs in the 90 days following discharge compared with the before-reform patients. No significant differences were observed in the overall number of opioid prescriptions written, PROs, or postoperative ED or hospital readmissions within 90 days in the year after the implementation of the prescribing reform.

CONCLUSIONS

Patients undergoing surgery in the year after the implementation of a state-level opioid prescribing reform received significantly fewer MEDs while reporting no change in the total number of opioid prescriptions, PROs, or postoperative ED visits or hospital readmissions. These results demonstrate that state-level reforms placing reasonable limits on opioid prescriptions written for acute pain may decrease patient opioid exposure without negatively impacting patient outcomes after lumbar decompression surgery.

摘要

目的

2017年8月31日,俄亥俄州实施了限制阿片类药物处方剂量和时长的立法。尽管此类限制已被广泛采用,但很少有研究调查这些改革对阿片类药物处方及患者预后的影响。在本研究中,作者旨在评估近期州级改革对阿片类药物处方、患者报告结局(PROs)以及择期腰椎减压手术后急诊就诊和再入院情况的影响。

方法

本研究为一项回顾性队列研究,研究对象为在全州改革实施前后数年间(2016年9月1日至2018年8月31日)于单一医疗系统内的5家医院之一接受退行性疾病择期腰椎板切除术的患者。根据手术时间相对于处方改革实施时间进行分类:改革前(2016年9月1日至2017年8月31日)或改革后(2017年9月1日至2018年8月31日)。感兴趣的结局包括术后出院后90天内门诊开具的阿片类药物总量(以吗啡当量剂量[MEDs]衡量)、开具的阿片类药物续方总数、术后首次门诊就诊时患者报告的疼痛(采用数字疼痛评分量表测量)、患者报告的健康相关生活质量改善情况(采用患者报告结局测量信息系统 - 总体健康[PROMIS - GH]问卷测量)以及术后90天内的急诊就诊或再入院情况。

结果

共有1031名患者符合该研究的纳入标准,改革前组和改革后组分别有469名和562名患者。与改革前患者相比,改革后患者出院后90天内接受的MEDs减少了26%(95%CI 19% - 32%)。在实施处方改革后的一年内,开具的阿片类药物处方总数、PROs或术后90天内的急诊就诊或再入院情况均未观察到显著差异。

结论

在州级阿片类药物处方改革实施后的一年内接受手术的患者,其接受的MEDs显著减少,而阿片类药物处方总数、PROs、术后急诊就诊或再入院情况均无变化。这些结果表明,对急性疼痛开具的阿片类药物处方进行合理限制的州级改革,可能会减少患者的阿片类药物暴露量,而不会对腰椎减压手术后的患者预后产生负面影响。

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