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管理贝塞斯达III级和IV级甲状腺结节的治疗选择:一项加拿大多机构研究。

Treatment Choices in Managing Bethesda III and IV Thyroid Nodules: A Canadian Multi-institutional Study.

作者信息

Kuta Victoria, Forner David, Azzi Jason, Curry Dennis, Noel Christopher W, Munroe Kelti, Bullock Martin, McDonald Ted, Taylor S Mark, Rigby Matthew H, Trites Jonathan, Johnson-Obaseki Stephanie, Corsten Martin J

机构信息

Division of Otolaryngology-Head & Neck Surgery, Queen Elizabeth II Health Sciences Center, Dalhousie University, Halifax, Canada.

Faculty of Medicine, University of Ottawa, Ottawa, Canada.

出版信息

OTO Open. 2021 Jun 24;5(2):2473974X211015937. doi: 10.1177/2473974X211015937. eCollection 2021 Apr-Jun.

Abstract

OBJECTIVE

Patient-centered decision making is increasingly identified as a desirable component of medical care. To manage indeterminate thyroid nodules, patients are offered the options of surveillance, diagnostic hemithyroidectomy, or molecular testing. Our objective was to identify factors associated with decision making in this population.

STUDY DESIGN

This is a retrospective cross-sectional study of patients with Bethesda III and IV thyroid nodules.

SETTING

Multi-institutional.

METHODS

Factors of interest included age, sex, socioeconomic status (SES), nodule size, institution, attending surgeon, surgeon payment model, and hospital type. Our outcome of interest was the initial management decision made by patients.

RESULTS

A total of 956 patients were included. The majority of patients had Bethesda III nodules (n = 738, 77%). A total of 538 (56%) patients chose surgery, 413 (43%) chose surveillance, and 5 (1%) chose molecular testing. There was a significant variation in management decision based on attending surgeon (proportion of patients choosing surgery: 15%-83%; ≤.0001). Fee-for-service surgeon payment models (odds ratio [OR], 1.657; 95% CI, 1.263-2.175; < .001) and community hospital settings (OR, 1.529; 95% CI, 1.145-2.042; < .001) were associated with the decision for surgery. Larger nodule size, younger patients, and Bethesda IV nodules were also associated with surgery.

CONCLUSION

While it seems appropriate that larger nodules, younger age, and higher Bethesda class were associated with decision for surgery, we also identified attending surgeon, surgeon payment model, and hospital type as important factors. Given this, standardizing management discussions may improve patient-centered shared decision making.

摘要

目的

以患者为中心的决策日益被视为医疗保健中一个理想的组成部分。对于甲状腺结节性质不确定的患者,可选择进行监测、诊断性半甲状腺切除术或分子检测。我们的目的是确定该人群中与决策相关的因素。

研究设计

这是一项对贝塞斯达Ⅲ级和Ⅳ级甲状腺结节患者的回顾性横断面研究。

研究地点

多机构。

方法

感兴趣的因素包括年龄、性别、社会经济地位(SES)、结节大小、机构、主治外科医生、外科医生薪酬模式和医院类型。我们感兴趣的结果是患者做出的初始治疗决策。

结果

共纳入956例患者。大多数患者有贝塞斯达Ⅲ级结节(n = 738,77%)。共有538例(56%)患者选择手术,413例(43%)选择监测,5例(1%)选择分子检测。基于主治外科医生的治疗决策存在显著差异(选择手术的患者比例:15% - 83%;P≤.0001)。按服务收费的外科医生薪酬模式(优势比[OR],1.657;95%置信区间[CI],1.263 - 2.175;P <.001)和社区医院环境(OR,1.529;95% CI,1.145 - 2.042;P <.001)与手术决策相关。较大的结节大小、较年轻的患者以及贝塞斯达Ⅳ级结节也与手术相关。

结论

虽然较大的结节、较年轻的年龄以及更高的贝塞斯达分级与手术决策相关似乎是合理的,但我们也确定主治外科医生、外科医生薪酬模式和医院类型是重要因素。鉴于此,规范治疗讨论可能会改善以患者为中心的共同决策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223b/8239982/59ce3603d776/10.1177_2473974X211015937-fig1.jpg

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