Yoshida Soichiro, Matsuoka Yoh, Toda Kazuma, Uehara Sho, Tanaka Hajime, Yokoyama Minato, Saito Kazutaka, Yoshimura Ryoichi, Fujii Yasuhisa
Department of Urology Tokyo Medical and Dental University Tokyo Japan.
Department of Radiation Therapeutics and Oncology Tokyo Medical and Dental University Tokyo Japan.
IJU Case Rep. 2021 May 3;4(4):228-230. doi: 10.1002/iju5.12294. eCollection 2021 Jul.
The efficacy of salvage local therapy after external beam radiotherapy has recently gained attention. However, a challenge with these therapies is the risk of significant genitourinary and gastrointestinal toxicity. Focal brachytherapy may be a treatment option because of its potential to reduce side effects.
A patient with castration-resistant prostate cancer was found to be free of metastases on whole-body magnetic resonance imaging following external beam radiotherapy, and prostate biopsy revealed a localized recurrence in the ventral prostate. The patient underwent salvage focal brachytherapy and had a prostate-specific antigen progression-free survival of 23 months. No adverse effects were observed following salvage brachytherapy.
Our case suggests that salvage focal brachytherapy may be an effective local treatment option for nonmetastatic castration-resistant prostate cancer that has relapsed after external beam radiotherapy, wherein the lesion is confined to a small area within the prostate.
外照射放疗后挽救性局部治疗的疗效近来受到关注。然而，这些治疗面临的一个挑战是存在显著的泌尿生殖系统和胃肠道毒性风险。聚焦近距离放射治疗因其有可能减少副作用，可能是一种治疗选择。
一名去势抵抗性前列腺癌患者在外照射放疗后行全身磁共振成像检查发现无转移，前列腺活检显示前列腺腹侧局部复发。该患者接受了挽救性聚焦近距离放射治疗，前列腺特异性抗原无进展生存期为23个月。挽救性近距离放射治疗后未观察到不良反应。
我们的病例表明，挽救性聚焦近距离放射治疗可能是外照射放疗后复发的非转移性去势抵抗性前列腺癌的一种有效局部治疗选择，其中病变局限于前列腺内的小区域。
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