Wise T G, Dolin R, Mazur M H, Top F H, Edelman R, Ennis F A
J Infect Dis. 1977 Dec;136 Suppl:S507-17. doi: 10.1093/infdis/136.supplement_3.s507.
Bivalent A/Victoria/75-A/New Jersey/76 and monovalent B/Hong Kong/72 influenza vaccines were given alone or together to adutls, and systemic reactions and antibody responses were determined. The rates of systemic reactivity observed varied among vaccine groups. Disrupted vaccines and whole-virus vaccines containing type B antigen only did not cause significant reactivity. Systemic reactions were observed after administration of the bivalent A whole-virus vaccines, and this reactivity was increased if the B vaccine was also administered. Reactions to the more reactive vaccines were less frequent in older subjects or in younger individuals with evidence of previous exposure to influenza antigens in the vaccine. Antibody responses in this study indicated that individuals older than 25 years responded better to A/New Jersey antigens than did younger subjects. The A/Victoria antigen produced lower antibody levels in older individuals than in younger subjects. The B/Hong Kong antibody responses were similar in all vaccine groups.
将二价A/维多利亚/75-A/新泽西/76流感疫苗和单价B/香港/72流感疫苗单独或联合接种给成年人，并测定全身反应和抗体反应。观察到的全身反应发生率在不同疫苗组中有所不同。裂解疫苗和仅含B型抗原的全病毒疫苗不会引起显著反应。接种二价A全病毒疫苗后观察到全身反应，如果同时接种B疫苗，这种反应会增强。在老年受试者或有证据表明以前接触过疫苗中流感抗原的年轻个体中，对反应性更强的疫苗的反应较少。本研究中的抗体反应表明，25岁以上的个体对A/新泽西抗原的反应比年轻受试者更好。A/维多利亚抗原在老年个体中产生的抗体水平低于年轻受试者。所有疫苗组中B/香港抗体反应相似。
