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阿那白滞素在类固醇依赖型复发性心包炎中的应用:一例病例报告及文献综述

Use of Anakinra in steroid dependent recurrent pericarditis: a case report and review of literature.

作者信息

Thallapally Vinay Kumar, Gupta Sonia, Gundepalli Sai Giridhar, Nahas Joseph

机构信息

Internal Medicine Department, Creighton University School of Medicine, Omaha, NE, USA.

出版信息

J Community Hosp Intern Med Perspect. 2021 Jun 21;11(4):543-546. doi: 10.1080/20009666.2021.1933716. eCollection 2021.

Abstract

Non-steroidal anti-inflammatory drugs and colchicine are the cornerstone treatment for recurrent pericarditis. Corticosteroids are frequently used in patients with recurrent episodes of pericarditis. In patients with corticosteroid dependent and corticosteroid-resistant pericarditis, several steroid-sparing options like azathioprine, intravenous immunoglobulin (IVIG), and anakinra are being recently tried. In this article, we present the case of a 44-year-old male with recurrent pericarditis, who was successfully treated with anakinra. : Non-steroidal anti-inflammatory drugs, NSAIDS; Aspirin, ASA; Erythrocyte sedimentation rate, ESR; Serum Protein Electrophoresis, SPEP; Magnetic Resonance Imaging, MRI; C-Reactive Protein, CRP; Aspartate Aminotransferase, AST; Alanine Aminotransferase, ALT; Idiopathic recurrent pericarditis, IRP; Intravenous Immunoglobulin, IVIG.

摘要

非甾体类抗炎药和秋水仙碱是复发性心包炎的基石性治疗药物。皮质类固醇常用于复发性心包炎患者。对于依赖皮质类固醇和皮质类固醇抵抗的心包炎患者,最近正在尝试几种减少类固醇使用的选择,如硫唑嘌呤、静脉注射免疫球蛋白(IVIG)和阿那白滞素。在本文中,我们介绍了一名44岁复发性心包炎男性患者,他通过阿那白滞素成功治愈。:非甾体类抗炎药,NSAIDS;阿司匹林,ASA;红细胞沉降率,ESR;血清蛋白电泳,SPEP;磁共振成像,MRI;C反应蛋白,CRP;天冬氨酸转氨酶,AST;丙氨酸转氨酶,ALT;特发性复发性心包炎,IRP;静脉注射免疫球蛋白,IVIG。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/664f/8262628/c829e0c4c4d2/ZJCH_A_1933716_F0001_B.jpg

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