Department of Periodontics, Institute of Dental Sciences, Siksha 'O' Anusandhan University, K8, Kalinga Nagar, Bhubaneswar, Odisha, India.
Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy.
J Biol Regul Homeost Agents. 2021 Mar-Apr;35(2 Suppl. 1):89-96. doi: 10.23812/21-2supp1-8.
Grape seed extract (GSE), a naturally producing polyphenolic compound, is found to be a potent hostmodulatory agent and considered for management of periodontal disease. Its anti-bacterial, antioxidant, and anti-inflammatory property may aid in achieving periodontal health. To assess the clinical efficacy of GSE in adjunct to scaling and root planing (SRP) in healing of periodontal pockets. The present study was a longitudinal, parallel design, randomized clinical trial. Seventy-two patients (mean age 39.2±8.6 years) with periodontal pockets were randomly divided into two groups; Test group received intra-pocket delivery of GSE with SRP and Control group received SRP alone. The clinical parameters like Plaque Index (PI), Gingival Index (GI), Probing Depth (PD) and Relative Attachment Level (RAL) were recorded at baseline and 3 months. 64 patients completed the study. Test group at the end of 3 months had statistically significant reduced PD (p=0.002) and RAL (p=0.01). No significant difference was observed for PI and GI at the end of 3 months. Intra-pocket application of GSE with SRP could be beneficial in management of periodontal pockets.
葡萄籽提取物（GSE）是一种天然产生的多酚化合物，被发现是一种有效的宿主调节剂，可用于治疗牙周病。其抗菌、抗氧化和抗炎特性可能有助于实现牙周健康。评估 GSE 联合龈下刮治和根面平整（SRP）治疗牙周袋的临床疗效。本研究为一项纵向、平行设计、随机临床试验。72 名（平均年龄 39.2±8.6 岁）患有牙周袋的患者被随机分为两组；试验组接受 GSE 局部给药联合 SRP 治疗，对照组仅接受 SRP 治疗。基线和 3 个月时记录菌斑指数（PI）、牙龈指数（GI）、探诊深度（PD）和相对附着水平（RAL）等临床参数。64 名患者完成了研究。试验组在 3 个月结束时 PD（p=0.002）和 RAL（p=0.01）有统计学显著降低。3 个月时 PI 和 GI 无显著差异。龈下刮治和根面平整联合 GSE 局部给药可能有助于牙周袋的管理。
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