Maternal spatial training before fertilization improves the spatial learning process in female offspring.

Recent results of our team showed that parental spatial training before fertilization improves the offspring's spatial memory. However, the process of spatial learning (short-term/working and long-term memories, mnesic consolidation and procedures) in the offspring has not been fully clarified yet. Therefore, this study aimed at specifically analyzing whether maternal learning of a spatial task before fertilization can impact on the process of spatial learning in the female offspring. In the present study, 8-week-old female Wistar rats that had been spatially trained (or not) in the Morris Water Maze (MWM) were mated with conspecific standard-reared male rats, and their 4-week-old female offspring were spatially tested in the same MWM to evaluate their learning and memory processes. Results showed that the female offspring of trained mothers significantly displayed lower escape latencies, higher swimming speed, shorter total distance swum, longer percentage of time spent in the target quadrant and better localization memory in comparison to the female offspring of not trained mothers. Further, MWM performances of mothers trained and their female offspring significantly correlated. These findings indicate that the maternal spatial training before fertilization improves the spatial learning and memory consolidation process of the female offspring.