IMol Polish Academy of Sciences, Warsaw, Poland.
Centre of New Technologies, University of Warsaw, Warsaw, Poland.
EMBO J. 2021 Aug 16;40(16):e109001. doi: 10.15252/embj.2021109001. Epub 2021 Jul 20.
Mitochondrial activity is becoming an inherent aspect of cellular protein homeostasis (proteostasis). In this issue, Schlagowski et al (2021) report on the attractive notion that modulating mitochondrial protein import activity stimulates protein aggregate clearance in the cytosol, thereby affecting cytosolic proteostasis and its collapse observed in neurodegenerative diseases.
线粒体活性正逐渐成为细胞蛋白质动态平衡(蛋白稳态)的固有组成部分。在本期中,Schlagowski 等人(2021 年)提出了一个颇具吸引力的观点,即调节线粒体蛋白输入活性可以刺激细胞质中蛋白聚集体的清除,从而影响细胞质蛋白动态平衡及其在神经退行性疾病中观察到的崩溃。