Shrikhande Shailesh V, Verma Manish
Department of Surgical Oncology, Tata Memorial Hospital, Ernest Borges Marg, Parel, Mumbai, 400012 India.
Medical Affairs, Sanofi, Mumbai, India.
Indian J Surg Oncol. 2021 Jun;12(2):279-285. doi: 10.1007/s13193-021-01281-0. Epub 2021 Mar 1.
Venous thromboembolism (VTE) is common in patients with cancer and is a leading cause of death. In addition to the hypercoagulable state associated with malignancy, cancer-related surgery and subsequent immobilization further increase the risk of VTE. Guidelines suggest extended prophylaxis up to 4 weeks with low-molecular-weight heparin (LMWH) in such patients. This study is conducted to determine the proportion of patients receiving thromboprophylaxis among those undergoing surgery for malignant abdominal or pelvic tumor. This prospective, multicenter, observational study included 300 patients (217 [72.3%] were women). Mean age and duration of cancer were 53.2 and 1.2 years, respectively. A total of 162 (54%) patients received thromboprophylaxis of which only pharmacological in 78 [48.1%], only mechanical in 27 [16.7%], and both pharmacological and mechanical in 57 [35.2%] patients. LMWH (128, 79.0%) and graduated compression stockings (74, 45.7%) were the commonly used modalities. VTE prophylaxis was given in only half of the patients. Physician education to increase adherence to international guidelines is very important. Trial Registration No. CTRI/2013/05/003617.
The online version contains supplementary material available at 10.1007/s13193-021-01281-0.
静脉血栓栓塞症（VTE）在癌症患者中很常见，是主要的死亡原因。除了与恶性肿瘤相关的高凝状态外，癌症相关手术及随后的制动会进一步增加VTE风险。指南建议对此类患者使用低分子肝素（LMWH）进行长达4周的延长预防。本研究旨在确定接受恶性腹部或盆腔肿瘤手术患者中接受血栓预防的患者比例。这项前瞻性、多中心、观察性研究纳入了300例患者（217例[72.3%]为女性）。癌症患者的平均年龄和病程分别为53.2岁和1.2年。共有162例（54%）患者接受了血栓预防，其中仅接受药物预防的有78例[48.1%]，仅接受机械预防的有27例[16.7%]，同时接受药物和机械预防的有57例[35.2%]。常用的预防方式为LMWH（128例，79.0%）和分级压力弹力袜（74例，45.7%）。只有一半的患者接受了VTE预防。提高医生对国际指南的依从性的教育非常重要。试验注册号：CTRI/2013/05/003617。
在线版本包含可在10.1007/s13193-021-01281-0获取的补充材料。
