Servicio de Otorrinolaringología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain.
Servicio de Otorrinolaringología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Acta Otorrinolaringol Esp (Engl Ed). 2021 Jul-Aug;72(4):222-229. doi: 10.1016/j.otoeng.2020.05.005.
The objective of this study is to assess the existence of differences in the epidemiological characteristics and prognosis of patients with head and neck squamous cell carcinoma (HNSCC) who smoke cigars.
We carried out a retrospective study of a cohort of 4500 patients with HNSCC treated during the period 1985-2017.
The proportion of cigar smokers was 2.4%, compared with 88.3% of cigarette smokers and 9.3% of non-smokers. There was an increase in the proportion of cigar smokers throughout the study period. With respect to cigarette smokers, cigar smokers had a higher proportion of male patients, a higher average age at diagnosis, and they had a higher frequency of tumours located in the oral cavity and hypopharynx. The results of a univariate analysis showed that the disease-specific survival of cigar smokers was lower than that of the other patients. Five-year disease-specific survival of cigar smokers was 60.9%, compared to 69.0% for non-smokers, 72.8% for smokers of less than 20 cigarettes/day, and 67.2% for smokers of more than 20 cigarettes/day. There were differences in the pattern of survival depending on tobacco consumption based on the location of the primary tumour.
A 2.4% of patients with HNSCC had a history of regular consumption of cigars. Disease-specific survival of cigar smokers was lower than that of other patients.
本研究旨在评估吸烟雪茄的头颈部鳞状细胞癌（HNSCC）患者的流行病学特征和预后是否存在差异。
我们对 1985 年至 2017 年间治疗的 4500 例 HNSCC 患者进行了回顾性队列研究。
雪茄烟民的比例为 2.4%，而香烟烟民的比例为 88.3%，非烟民的比例为 9.3%。在整个研究期间，雪茄烟民的比例有所增加。与香烟烟民相比，雪茄烟民中男性患者比例较高，诊断时的平均年龄较高，且口腔和下咽部位肿瘤的发生率较高。单因素分析结果表明，雪茄烟民的疾病特异性生存率低于其他患者。雪茄烟民的 5 年疾病特异性生存率为 60.9%，而非烟民为 69.0%，每天吸烟少于 20 支的烟民为 72.8%，每天吸烟超过 20 支的烟民为 67.2%。根据原发肿瘤的位置，基于烟草消费模式的生存模式存在差异。
2.4%的 HNSCC 患者有规律吸食雪茄的病史。雪茄烟民的疾病特异性生存率低于其他患者。
