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在哥伦比亚特区队列中,整合酶链转移抑制剂与围产期感染人类免疫缺陷病毒的儿童和青少年体重增加的关系

Integrase Strand Transfer Inhibitors and Weight Gain in Children and Youth With Perinatal Human Immunodeficiency Virus in the DC Cohort.

作者信息

Koay Wei Li A, Dirajlal-Fargo Sahera, Levy Matthew E, Kulie Paige, Monroe Anne, Castel Amanda D, Rakhmanina Natella Y

机构信息

Department of Infectious Diseases, Children's National Hospital, Washington, District of Columbia, USA.

School of Medicine and Health Sciences, George Washington University, Washington, District of Columbia, USA.

出版信息

Open Forum Infect Dis. 2021 Jul 1;8(7):ofab308. doi: 10.1093/ofid/ofab308. eCollection 2021 Jul.

Abstract

We conducted a retrospective analysis of 38 children and youth with human immunodeficiency virus (aged 0-19 years) in the United States and report an increased rate of change of BMI-for-age score after initiating integrase strand transfer inhibitors (+0.19 score units/year [95% confidence interval, .01-.37];  = .036) for a median follow-up of 527.5 days.

摘要

我们对美国38名感染人类免疫缺陷病毒的儿童和青少年(年龄在0至19岁之间)进行了回顾性分析,并报告称,在开始使用整合酶链转移抑制剂后,年龄别体重指数评分的变化率有所增加(+0.19评分单位/年[95%置信区间,0.01 - 0.37];P = 0.036),中位随访时间为527.5天。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a7c/8291625/39add5d9b59f/ofab308f0001.jpg

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