新的治疗策略：胰腺癌治疗的个性化——不可逆电穿孔（IRE）、电化学疗法（ECT）和钙电穿孔（CaEP）——一项临床前初步研究。
New therapeutic strategy: Personalization of pancreatic cancer treatment-irreversible electroporation (IRE), electrochemotherapy (ECT) and calcium electroporation (CaEP) - A pilot preclinical study.
作者信息
Rudno-Rudzińska Julia, Kielan Wojciech, Guziński Maciej, Płochocki Maciej, Antończyk Agnieszka, Kulbacka Julita
机构信息
Department of General and Oncological Surgery, Medical University Hospital, Borowska 213, 50-556, Wroclaw, Poland.
Department of General and Oncological Surgery, Medical University Hospital, Borowska 213, 50-556, Wroclaw, Poland.
出版信息
Surg Oncol. 2021 Sep;38:101634. doi: 10.1016/j.suronc.2021.101634. Epub 2021 Jul 21.
In this study, irreversible electroporation (IRE), electrochemotherapy (ECT), and calcium electroporation (CaEP) techniques were investigated as new strategies for human pancreatic cancer. Qualification of the patients, best "therapeutic moment" for each patient, safety, and complications after procedures were examined. In this pilot study were included 13 patients in this study, which were operated on in different pancreatic cancer stages. Patients underwent IRE or ECT with intravenous admission of cisplatin or electroporation with calcium intratumoral administration. The IRE procedure was safe for the patients. Medium overall survival for IRE, IRE + CTH, and IRE + CaCl was respectively: 16, 29.5, and 19 months comparing to 10 months in control chemotherapy (CTH) group. Thus, IRE, ECT, and CaEP can be effective strategies for pancreatic cancer treatment.
在本研究中，不可逆电穿孔（IRE）、电化学疗法（ECT）和钙电穿孔（CaEP）技术作为治疗人类胰腺癌的新策略进行了研究。对患者的资格、每位患者的最佳“治疗时机”、安全性以及术后并发症进行了检查。本前瞻性研究纳入了13例处于不同胰腺癌阶段并接受手术的患者。患者接受了IRE或ECT治疗，静脉注射顺铂，或接受肿瘤内注射钙的电穿孔治疗。IRE手术对患者是安全的。IRE、IRE + CTH和IRE + CaCl的中位总生存期分别为：16个月、29.5个月和19个月，而对照化疗（CTH）组为10个月。因此，IRE、ECT和CaEP可能是治疗胰腺癌的有效策略。
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