Oshima T, Matsuura H, Kido K, Matsumoto K, Otsuki T, Fujii H, Masaoka S, Okamoto M, Tsuchioka Y, Kajiyama G
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Jpn Circ J. 1987 Oct;51(10):1184-90. doi: 10.1253/jcj.51.1184.
In order to clarify the relation between salt sensitivity and changes in intracellular sodium ([Na]i) and free calcium concentration ([Ca2+]i) after salt loading, [Na]i and [Ca2+]i were determined in lymphocytes of twenty patients with essential hypertension under a low salt diet (3 g/day) and a high salt diet (20 g/day) for seven days, respectively. They were classified as "salt-sensitive" (n = 10) or "nonsalt-sensitive" (n = 10) on the basis of the changes in blood pressure after salt loading. Both lymphocytic [Na]i and [Ca2+]i were significantly increased with salt loading in salt-sensitive patients (p less than 0.05 for both), while they were not affected by salt loading in nonsalt-sensitive patients. Lymphocytic [Ca2+]i showed a positive correlation with lymphocytic [Na]i under both low salt diet (r = 0.62, p less than 0.01) and high salt diet (r = 0.70, p less than 0.01) in all patients in both groups. In addition, a close and positive correlation was observed between the changes in lymphocytic [Na]i and those in lymphocytic [Ca2+]i after salt loading in all patients in both groups (r = 0.80, p less than 0.001). These results suggest that the increase in [Ca2+]i, possibly linked with the increase in [Na]i, may be involved in elevation of blood pressure in the salt-sensitive patients after salt loading.
为了阐明盐敏感性与盐负荷后细胞内钠浓度（[Na]i）及游离钙浓度（[Ca2+]i）变化之间的关系，分别对20例原发性高血压患者在低盐饮食（3克/天）和高盐饮食（20克/天）条件下进行为期7天的研究，测定其淋巴细胞内的[Na]i和[Ca2+]i。根据盐负荷后血压的变化，将他们分为“盐敏感型”（n = 10）和“非盐敏感型”（n = 10）。盐敏感型患者盐负荷后淋巴细胞内的[Na]i和[Ca2+]i均显著升高（两者p均小于0.05），而非盐敏感型患者则不受盐负荷影响。在两组所有患者中，低盐饮食（r = 0.62，p小于0.01）和高盐饮食（r = 0.70，p小于0.01）条件下淋巴细胞内的[Ca2+]i均与[Na]i呈正相关。此外，两组所有患者盐负荷后淋巴细胞内[Na]i的变化与[Ca2+]i的变化之间均观察到密切的正相关（r = 0.80，p小于0.001）。这些结果表明，[Ca2+]i的升高可能与[Na]i的升高有关，可能参与了盐敏感型患者盐负荷后血压的升高。
