Coccidiosis, caused by various species, is a major parasitic disease in chickens. Our understanding of how chickens respond to coccidian infections is highly limited at both the molecular and cellular levels. In this study, coexpression modules were identified by weighted gene coexpression network analysis in chickens infected with . A total of 15 correlation modules were identified using 5,175 genes with 24 chicken samples, 12 with primary and 12 with secondary infection. The analysis of the interactions between these modules showed a high degree of scale independence. Gene Ontology and Kyoto Encyclopedia of Gene and Genomes enrichment analyses revealed that genes in these functional modules were involved in a broad categories of functions, such as immune response, amino acid metabolism, cellular responses to lipids, sterol biosynthetic processes, and RNA transport. Two modules viz yellow and magenta were identified significantly associating with infection status. Preservation analysis showed that most of the modules identified in infections were highly or moderately preserved in chickens infected with either or . These analyses outline a biological responses landscape for chickens infected by , and also indicates that infections with these three species elicit similar biological responses in chickens at the system level. These findings provide new clues and ideas for investigating the relationship between parasites and host, and the control of parasitic diseases.