Perkins Daniel, Opaleye Emerita S, Simonova Hana, Bouso José C, Tófoli Luís F, GalvÃo-Coelho Nicole L, Schubert Violeta, Sarris Jerome
School of Social and Political Science, University of Melbourne, Melbourne, Australia.
Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.
Drug Alcohol Rev. 2022 Jan;41(1):265-274. doi: 10.1111/dar.13348. Epub 2021 Jul 25.
Emerging evidence suggests that psychedelic compounds, including the Amazonian botanical decoction ayahuasca, may provide clinical benefit in the treatment of alcohol or other drug use disorders. This study investigates associations between ayahuasca consumption in naturalistic settings and current alcohol and other drug use.
Online cross-sectional study of people who have consumed ayahuasca in religious, traditional and non-traditional settings in over 40 countries. A total of 8629 participants (53% male, average age 40 years) were included in the analysis. Logistic regressions were used to explore associations between ayahuasca drinking variables and the current use of alcohol and other drugs, as well as the influence of confounding factors, such as church or community membership.
The number of times ayahuasca had been consumed was strongly associated with increased odds of never or rarely drinking alcohol, never or rarely engaging in 'risky drinking' and having not consumed a range of drugs in the past month, with these effects greater for those with a prior substance use disorder compared to those without. The strength of ayahuasca drinkers subjective spiritual experience, number of personal self-insights obtained and drinking ayahuasca with an ayahuasca church were also associated with lower substance use in some models.
Consumption of ayahuasca in naturalistic settings is associated with lower self-reported current consumption of alcohol and other drugs for those with and without prior substance use disorders, with such effects present after adjusting for religious or social group effects.
新出现的证据表明，包括亚马逊植物煎剂死藤水在内的迷幻化合物可能在治疗酒精或其他药物使用障碍方面具有临床益处。本研究调查了在自然环境中饮用死藤水与当前酒精及其他药物使用之间的关联。
对在40多个国家的宗教、传统和非传统环境中饮用过死藤水的人群进行在线横断面研究。共有8629名参与者（53%为男性，平均年龄40岁）纳入分析。采用逻辑回归来探讨饮用死藤水变量与当前酒精及其他药物使用之间的关联，以及混杂因素的影响，如教会或社区成员身份。
饮用死藤水的次数与从不或很少饮酒、从不或很少进行“危险饮酒”以及在过去一个月未使用一系列药物的几率增加密切相关，与没有物质使用障碍的人相比，有物质使用障碍史的人这种影响更大。在一些模型中，死藤水饮用者主观精神体验的强度、获得的个人自我洞察数量以及与死藤水教会一起饮用死藤水也与较低的物质使用相关。
对于有或没有物质使用障碍史的人来说，在自然环境中饮用死藤水与自我报告的当前酒精及其他药物使用量较低有关，在调整宗教或社会群体影响后仍存在这种影响。
