Bullor Carolina, Martínez Deocare Daniela, Rodríguez Brenda, Zuzel Paula Y, Aliano Johanna, Marqués Burgos Paula, Nuñez Ignacio, Díaz Pumará Estanislao
Unidad 6 de Clínica Pediátrica, Hospital de Niños Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires, Argentina.
Arch Argent Pediatr. 2021 Aug;119(4):e326-e329. doi: 10.5546/aap.2021.e326.
Pseudo-thrombotic microangiopathy, or Moschcowitz syndrome, is a rare manifestation of vitamin B12 deficiency. It is characterized by microangiopathic hemolytic anemia, reticulocytes, and hematimetric indices that can be normal or that might present a mild megaloblastosis, and which are associated with neurological manifestations. Vitamin B12 can be found in animal-based protein foods. Breastfeeding is an adequate source of this vitamin for children, when maternal serum levels are normal. The case of a 16-month-old infant is presented. She was admitted for hemolytic anemia with transfusion requirement, thrombocytopenia, failure to thrive and developmental delay. During her hospitalization, she was diagnosed with pseudothrombotic microangiopathy caused by vitamin B12 deficiency.
假性血栓性微血管病,即Moschcowitz综合征,是维生素B12缺乏的一种罕见表现。其特征为微血管病性溶血性贫血、网织红细胞,以及血细胞计数指标可正常或可能呈现轻度巨幼细胞性变,并伴有神经学表现。维生素B12可在动物性蛋白食物中找到。当母亲血清水平正常时,母乳喂养是儿童获取这种维生素的充足来源。本文介绍了一名16个月大婴儿的病例。她因溶血性贫血伴输血需求、血小板减少、生长发育迟缓而入院。住院期间,她被诊断为维生素B12缺乏所致的假性血栓性微血管病。