中国高血压人群中体重指数与外周动脉疾病风险的U型关联
U-Shaped Association of Body Mass Index with the Risk of Peripheral Arterial Disease in Chinese Hypertensive Population.
作者信息
Li Junpei, Yu Shichao, Zhou Wei, Zhu Linjuan, Wang Tao, Bao Huihui, Huang Xiao, Cheng Xiaoshu
机构信息
Department of Cardiovascular, the Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, People's Republic of China.
Qinghua Health Center, Wuyuan, People's Republic of China.
出版信息
Int J Gen Med. 2021 Jul 20;14:3627-3634. doi: 10.2147/IJGM.S323769. eCollection 2021.
BACKGROUND
High body mass index (BMI) is a well-recognized risk factor for cardiovascular diseases. But its role in peripheral artery disease (PAD) remains perplexing. Our study aims to evaluate the association of BMI with PAD in the Chinese hypertensive population.
METHODS
This is a cross-sectional study with enrollment data from the Chinese H-type Hypertension Registry.10896 hypertensive patients aged ≥18 years were included in the final analysis.
RESULTS
The prevalence of PAD diagnosed by ABI in this study was 3.2% (n=351). A U-shaped association between BMI and PAD was found. Per SD increment (3.6 kg/m) on the left side of the BMI threshold (BMI < 25.7 kg/m) was associated with a 27% decrease in the adjusted risk of PAD [OR, 0.73; 95% confidence interval (CI) 0.60, 0.89; P=0.002]; BMI was significantly positively associated with the risk of PAD (OR, 1.52; 95% CI 1.52, 1.93; P=0.001) in those with BMI ≥25.7 kg/m.
CONCLUSION
In summary, a U-shaped association between BMI and the risk of PAD in the Chinese hypertensive population was found. BMI with the lowest risk of PAD was estimated to be 25.7 kg/m.
背景
高体重指数（BMI）是心血管疾病公认的危险因素。但其在周围动脉疾病（PAD）中的作用仍不明确。我们的研究旨在评估中国高血压人群中BMI与PAD的关联。
方法
这是一项横断面研究，采用中国H型高血压登记研究的入组数据。最终分析纳入了10896例年龄≥18岁的高血压患者。
结果
本研究中通过踝臂指数（ABI）诊断的PAD患病率为3.2%（n = 351）。发现BMI与PAD之间呈U型关联。在BMI阈值左侧（BMI < 25.7 kg/m²），每标准差增加（3.6 kg/m²）与PAD校正风险降低27%相关[比值比（OR），0.73；95%置信区间（CI）0.60，0.89；P = 0.002]；在BMI≥25.7 kg/m²的人群中，BMI与PAD风险显著正相关（OR，1.52；95% CI 1.52，1.93；P = 0.001）。
结论
总之，在中国高血压人群中发现BMI与PAD风险之间呈U型关联。估计PAD风险最低的BMI为25.7 kg/m²。
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