Chair and Department of Hygiene, Medical University of Lublin, Radziwillowska 11 Street, 20-080 Lublin, Poland; Doctoral School, Medical University of Lublin, Poland.
Chair and Department of Hygiene, Medical University of Lublin, Radziwillowska 11 Street, 20-080 Lublin, Poland.
Biomed Pharmacother. 2021 Sep;141:111938. doi: 10.1016/j.biopha.2021.111938. Epub 2021 Jul 22.
Ketoprofen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Side effects of ketoprofen occur mainly from the gastrointestinal tract due to the inhibition of cyclooxygenaze-1. Binge drinking at least once a week is reported by 80 million Europeans. On the day after many of them use NSAIDs. This increases the risk for damage of gastric mucosa.
The aim of the study was to check if use of ketoprofen lysine salt (KLS) has any gastroprotective effect on mucosa of rat stomach after ethyl alcohol intoxication.
There were 6 groups of 6 male rats which received: RESULTS: In groups 1, 2 and 3 the histopathologic examination of the stomachs revealed normal picture, without signs of inflammation. In the group 4, 5 and 6 within the mucosa and submucosa there were visible numerous infiltrates of inflammatory cells, consisting mainly of lymphocytes, plasmocytes and eosinophilia. Total leukocyte count was elevated in group 3, 4, 6. There was a significant decrease of blood urea concentration in group 6 vs 2 and significant decrease of serum albumin in group 6 vs 1 and 2, and total protein vs group 1.
Side effects of ketoprofen occur mainly from the gastrointestinal tract. KLS has no gastroprotective effect after ethanol-gastric injury and does not protect gastric mucosa from damage produced by binge drinking. Therefore it should not be used after drinking distilled spirits.
酮洛芬是一种常用的非甾体抗炎药（NSAID），具有镇痛和解热作用。酮洛芬的副作用主要来自胃肠道，因为它抑制环氧化酶-1。据报道，8000 万欧洲人每周至少狂饮一次。在他们中的许多人使用 NSAIDs 的第二天。这增加了胃黏膜损伤的风险。
本研究的目的是检查酮洛芬赖氨酸盐（KLS）在乙醇中毒后对大鼠胃黏膜是否有任何胃保护作用。
有 6 组 6 只雄性大鼠分别接受：
在第 1、2 和 3 组中，胃的组织病理学检查显示正常，没有炎症迹象。在第 4、5 和 6 组中，黏膜和黏膜下层可见大量炎症细胞浸润，主要由淋巴细胞、浆细胞和嗜酸性粒细胞组成。第 3、4、6 组白细胞总数升高。第 6 组的血尿素浓度与第 2 组相比显著降低，第 6 组的血清白蛋白与第 1 组和第 2 组相比显著降低，总蛋白与第 1 组相比显著降低。
酮洛芬的副作用主要来自胃肠道。KLS 对乙醇性胃损伤没有胃保护作用，不能保护胃黏膜免受狂饮引起的损伤。因此，不应在饮用蒸馏酒后使用。
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