Department of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postępu 36A, Jastrzebiec, Poland.
Faculty of Pharmacy with the Laboratory Medicine Division, Department of Pharmacodynamics, Medical University of Warsaw, Centre for Preclinical Research and Technology, Banacha 1B, Warsaw, Poland.
Mediators Inflamm. 2021 Jul 10;2021:4977209. doi: 10.1155/2021/4977209. eCollection 2021.
Cardiovascular disease (CVD) is the leading cause of death worldwide. The most dangerous life-threatening symptoms of CVD are myocardial infarction and stroke. The causes of CVD are not entirely clear, and new therapeutic targets are still being sought. One of the factors involved in CVD development among vascular damage and oxidative stress is chronic inflammation. It is known that hyaluronic acid plays an important role in inflammation and is regulated by numerous stimuli, including proinflammatory cytokines. The main receptors for hyaluronic acid are CD44 and RHAMM. These receptors are membrane proteins that differ in structure, but it seems that they can perform similar or synergistic functions in many diseases. Both RHAMM and CD44 are involved in cell migration and wound healing. However, their close association with CVD is not fully understood. In this review, we describe the role of both receptors in CVD.
心血管疾病（CVD）是全球范围内的主要死亡原因。心血管疾病最危险的危及生命的症状是心肌梗死和中风。CVD 的病因并不完全清楚，仍在寻找新的治疗靶点。血管损伤和氧化应激导致心血管疾病发展的一个因素是慢性炎症。已知透明质酸在炎症中发挥重要作用，并且受到多种刺激的调节，包括促炎细胞因子。透明质酸的主要受体是 CD44 和 RHAMM。这些受体是结构不同的膜蛋白，但它们在许多疾病中似乎可以发挥相似或协同的功能。RHAMM 和 CD44 都参与细胞迁移和伤口愈合。然而，它们与 CVD 的密切关联尚未完全了解。在这篇综述中，我们描述了这两种受体在 CVD 中的作用。
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