肝脏X受体在慢性过敏性哮喘小鼠气道重塑中的作用
Role of liver-X-receptors in airway remodeling in mice with chronic allergic asthma.
作者信息
Zhang Jinmei, Wu Zhengcan, Yu Fenfang, Ye Liang, Gu Wei, Tan Yan, Wang Li, Shi Ying
机构信息
Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China.
Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China.
出版信息
Exp Ther Med. 2021 Sep;22(3):920. doi: 10.3892/etm.2021.10352. Epub 2021 Jun 30.
Liver X receptors (LXRs) exert anti-inflammatory effects in animal models of certain respiratory diseases. In the present study, a model of chronic airway remodeling was established in wild-type and LXR-deficient mice. Ovalbumin (OVA)-sensitized mice were chronically administered OVA via inhalation for 8 weeks. Prior to each stimulation, certain wild-type mice were treated with GW3965, which is a highly selective LXR agonist. The influence of LXRs on airway inflammation, airway hyperresponsiveness and airway remodeling was evaluated. LXRs were indicated to increase airway inflammation and airway hyperresponsiveness, as well as promote airway remodeling. These results suggest that inhibiting LXRs may be a potential method for the treatment of allergic asthma.
肝X受体（LXRs）在某些呼吸道疾病的动物模型中发挥抗炎作用。在本研究中，在野生型和LXR缺陷型小鼠中建立了慢性气道重塑模型。用卵清蛋白（OVA）致敏的小鼠通过吸入法长期给予OVA，持续8周。在每次刺激前，对某些野生型小鼠用GW3965进行处理，GW3965是一种高度选择性的LXR激动剂。评估了LXRs对气道炎症、气道高反应性和气道重塑的影响。结果表明，LXRs会加重气道炎症和气道高反应性，并促进气道重塑。这些结果提示，抑制LXRs可能是治疗过敏性哮喘的一种潜在方法。
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