Street Adam, Jerome Mairin A, Williams Christopher J
Department of Orthopedics and Sports Medicine, Emory University, Atlanta, USA.
Interventional Orthopedics and Regenerative Medicine, Interventional Orthopedics of Atlanta, Atlanta, USA.
Cureus. 2021 Jul 27;13(7):e16677. doi: 10.7759/cureus.16677. eCollection 2021 Jul.
Osteonecrosis (ON) is a painful condition involving bony cell death with resultant architectural collapse. This report discusses the case of a 50-year-old Caucasian female who presented to an outpatient musculoskeletal clinic with severe chronic left knee pain. She had a history of ulcerative colitis and resultant chronic corticosteroid exposure with subsequent development of knee ON. She was treated with an intraosseous autologous bone marrow concentrate (BMC), demineralized bone matrix (DBM), and platelet-rich plasma (PRP) injection. At 11 months post-injection, she demonstrated a significant improvement in pain scores, mobility, activity, and decreased narcotic use. Intraosseous orthobiologic injection for the treatment of knee ON is a promising procedure with a reasonable safety profile that warrants further study as an alternative to surgical intervention.
骨坏死（ON）是一种疼痛性疾病，涉及骨细胞死亡并导致结构塌陷。本报告讨论了一名50岁的白种女性病例，她因左膝严重慢性疼痛就诊于门诊肌肉骨骼诊所。她有溃疡性结肠炎病史，因长期使用皮质类固醇导致膝部骨坏死。她接受了骨内自体骨髓浓缩物（BMC）、脱矿骨基质（DBM）和富血小板血浆（PRP）注射治疗。注射后11个月，她的疼痛评分、活动能力、日常活动有显著改善，并且减少了麻醉药物的使用。骨内注射矫形生物制剂治疗膝部骨坏死是一种有前景的治疗方法，安全性合理，作为手术干预的替代方法值得进一步研究。
