5 岁患儿因白细胞介素-36 受体拮抗剂（DITRA）缺乏导致严重头皮和指甲受累，使用司库奇尤单抗后迅速起效。
Rapid response to secukinumab in a 5-year-old with deficiency of the interleukin-36 receptor antagonist (DITRA) with severe scalp and nail involvement.
机构信息
Department of Dermatology, University of Hong Kong Shenzhen Hospital, Shenzhen, China.
出版信息
Pediatr Dermatol. 2021 Sep;38(5):1258-1263. doi: 10.1111/pde.14737. Epub 2021 Aug 2.
PMID:34339530
Abstract
Deficiency of the interleukin-36 receptor antagonist (DITRA) is an autosomal recessive disease caused by mutations of the IL36RN gene. DITRA is characterized by acute generalized pustular psoriasis (GPP), fever, systemic inflammation, and leukocytosis. We report the case of a 5-year-old girl with severe scalp and nail involvement with a rapid response to secukinumab.
摘要
白细胞介素-36 受体拮抗剂（DITRA）缺乏症是一种常染色体隐性疾病，由 IL36RN 基因突变引起。DITRA 的特征是急性泛发性脓疱性银屑病（GPP）、发热、全身炎症和白细胞增多。我们报告了一例 5 岁女孩，头皮和指甲严重受累，对司库奇尤单抗有快速反应。
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