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实体器官移植患者的转子间骨折固定:结局和存活率。

Intertrochanteric fracture fixation in solid organ transplant patients: outcomes and survivorship.

机构信息

Department of Orthopedic Surgery, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

出版信息

Arch Orthop Trauma Surg. 2022 Oct;142(10):2739-2745. doi: 10.1007/s00402-021-04096-4. Epub 2021 Aug 3.

Abstract

BACKGROUND

Solid organ transplantation (SOT) recipients have complex medical and surgical risk factors; however, the outcomes of these patients undergoing surgical fixation of hip fractures are unknown. This study sought to evaluate SOT patients' outcomes and survivorship after intertrochanteric (IT) fracture fixation.

METHODS

A retrospective review identified 12 SOT patients who underwent cephalomedullary (CMN) nail fixation for IT fractures and were matched (1:2) to a cohort of 24 non-SOT IT fracture patients. Perioperative results and complications, mortality/patient survivorship, and clinical outcomes were compared between the cohorts.

RESULTS

The time from presentation to surgical fixation was within 48 h of presentation for the non-SOT patients, while only 75% of SOT patients underwent surgery within 48 h of presentation (p = 0.034). The 90-day readmission rate for SOT patients was 25% versus 13% in the non-SOT group (p = 0.38). Similarly, the SOT cohort experienced a higher rate of major medical complication (25% vs. 13%, p = 0.38). There were two (16%) reoperations in the SOT group and three (13%) in the non-SOT matched group (p = 0.99). Respectively, the 90-day and 1-year estimated patient survivorship was similar between the two cohorts: SOT patients with 92% (95% CI 54-99%) and 73% (95% CI 24-93%) versus 86% (95% CI 62-95%) and 72% (95% CI 47-86%, HR 0.92, 95% CI 0.18-4.62, p = 0.92) in non-SOT patients.

CONCLUSION

SOT patients who underwent CMN fixation for IT fractures required more time from hospital presentation to surgical management than non-SOT patients. Although not statistically significant, SOT patients demonstrated more acute complications and readmissions, but similar mortality compared to those without transplant.

摘要

背景

实体器官移植(SOT)受者具有复杂的医学和手术风险因素;然而,这些患者接受髋关节骨折手术固定的结果尚不清楚。本研究旨在评估 SOT 患者接受股骨近端髓内钉(CMN)固定治疗股骨转子间骨折的结果和生存率。

方法

回顾性分析了 12 例接受 CMN 固定治疗股骨转子间骨折的 SOT 患者,并与 24 例非 SOT 股骨转子间骨折患者进行了匹配(1:2)。比较了两组患者的围手术期结果和并发症、死亡率/患者生存率和临床结果。

结果

非 SOT 患者从就诊到手术固定的时间在就诊后 48 小时内,而只有 75%的 SOT 患者在就诊后 48 小时内接受手术(p=0.034)。SOT 患者的 90 天再入院率为 25%,而非 SOT 组为 13%(p=0.38)。同样,SOT 组发生主要医疗并发症的比例较高(25%比 13%,p=0.38)。SOT 组有 2 例(16%)再次手术,非 SOT 匹配组有 3 例(13%)(p=0.99)。分别为,两组患者的 90 天和 1 年患者生存率相似:SOT 患者为 92%(95%CI 54-99%)和 73%(95%CI 24-93%),而非 SOT 患者为 86%(95%CI 62-95%)和 72%(95%CI 47-86%)(HR 0.92,95%CI 0.18-4.62,p=0.92)。

结论

接受 CMN 固定治疗股骨转子间骨折的 SOT 患者从就诊到手术治疗的时间长于非 SOT 患者。尽管没有统计学意义,但 SOT 患者表现出更多的急性并发症和再入院,但与未接受移植的患者相比,死亡率相似。

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