一例源自马尔尼菲篮状菌感染所致淋巴结病的上腹部肿块：病例报告
A mass in the upper abdomen derived from Talaromyces marneffei infected lymphadenopathy: a case report.
作者信息
Chen Xue, Jia Lin, Wu Yongfeng, Chang Jing, Zhang Tong, Ma Yingmin, Zhang Yulin
机构信息
Department of Respiratory and Infectious Diseases, Beijing You An Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, 100069, China.
Pathology Diagnostic Center, Beijing You An Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, 100069, China.
出版信息
BMC Infect Dis. 2021 Aug 4;21(1):750. doi: 10.1186/s12879-021-06489-7.
BACKGROUND
An upper abdominal mass without tenderness often indicates a benign or malignant tumor once liver or spleen hyperplasia has been excluded. A lymphadenopathic mass from Talaromyces marneffei infection is rare.
CASE PRESENTATION
We report the case of a 29-year-old human immunodeficiency virus (HIV) infected man who presented with an upper abdominal mass and without any symptoms related with infection. Histopathology and next-generation sequencing (NGS) following biopsy of the mass confirmed T. marneffei-infected lymphadenopathy, and the patient was successfully treated with amphotericin B and itraconazole.
CONCLUSIONS
This case report suggests that potential fungal infection should be considered during the diagnostic workup of a mass in clinical practice.
背景
排除肝脏或脾脏增生后，上腹部无压痛肿块常提示良性或恶性肿瘤。马尔尼菲篮状菌感染引起的淋巴结病性肿块较为罕见。
病例报告
我们报告一例29岁的人类免疫缺陷病毒（HIV）感染者，其出现上腹部肿块且无任何感染相关症状。肿块活检后的组织病理学检查和二代测序（NGS）证实为马尔尼菲篮状菌感染的淋巴结病，患者接受两性霉素B和伊曲康唑治疗后痊愈。
结论
本病例报告提示，在临床实践中，对上腹部肿块进行诊断检查时应考虑潜在的真菌感染。
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