Department of Obstetrics and Gynecology, Division of Biostatistics, and the Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, and the Feinberg School of Medicine, Northwestern University, Chicago Illinois; and the Section of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven Connecticut.
Obstet Gynecol. 2021 Sep 1;138(3):426-433. doi: 10.1097/AOG.0000000000004518.
To create a prediction model for external cephalic version (ECV) success using objective patient characteristics.
This retrospective study included pregnant individuals of at least 18 years of age with a nonanomalous, singleton gestation who underwent an ECV attempt between 2006 and 2016 at a single quaternary care hospital. Variables assessed included maternal age, height, weight, body mass index (BMI), parity, fetal sex, gestational age, estimated fetal weight, type of fetal malpresentation, placental location, and amniotic fluid volume. Univariable and multivariable logistic regression models were used to determine the association of patient characteristics with ECV success. Estimated odds ratios and corresponding 95% CIs were calculated for each variable, and backward elimination and bootstrapping were used to find a parsimonious model for ECV success with the highest discriminatory capacity (as determined by the area under the receiver operating characteristic curve [AUC]). This model was evaluated with a calibration curve across deciles of success.
A total of 1,138 individuals underwent an ECV attempt and were included in this analysis. The overall ECV success frequency was 40.6%. Factors significantly associated with ECV success were maternal age, parity, placental location, estimated fetal weight, and type of fetal malpresentation. A final model with BMI, parity, placental location, and type of fetal malpresentation had the highest AUC (0.667 [95% CI 0.634-0.701]), resulted in good calibration, and is represented by the following equation: 1/[1+e-x] where x=1.1726-0.0314 (BMI)-0.9299 (nulliparity)+1.0218 (transverse or oblique presentation at ECV)-0.5113 (anterior placenta). An interactive version of this equation was created and can be accessed at www.ecvcalculator.com.
A prediction model that estimates the probability of ECV success was created and internally validated. This model incorporates easily obtainable and objective patient factors known before ECV and may be used in decision making and patient counseling about ECV.
利用客观的患者特征创建一种预测外部头位倒转(ECV)成功的模型。
本回顾性研究纳入了 2006 年至 2016 年期间在一家单四级保健医院接受 ECV 尝试的至少 18 岁的非畸形、单胎妊娠孕妇。评估的变量包括母亲的年龄、身高、体重、体重指数(BMI)、产次、胎儿性别、孕龄、估计胎儿体重、胎儿胎位异常类型、胎盘位置和羊水体积。使用单变量和多变量逻辑回归模型来确定患者特征与 ECV 成功的关系。为每个变量计算估计的优势比及其对应的 95%置信区间(CI),并使用向后消除和引导法来找到具有最高判别能力(由接收者操作特征曲线下面积[AUROC]确定)的简洁 ECV 成功模型。使用成功率的十分位数校准曲线来评估该模型。
共有 1138 人接受了 ECV 尝试,并纳入了本分析。总体 ECV 成功率为 40.6%。与 ECV 成功显著相关的因素是母亲的年龄、产次、胎盘位置、估计胎儿体重和胎儿胎位异常类型。具有 BMI、产次、胎盘位置和胎儿胎位异常类型的最终模型具有最高的 AUROC(0.667 [95%CI 0.634-0.701]),校准效果良好,由以下方程表示:1/[1+e-x],其中 x=1.1726-0.0314(BMI)-0.9299(初产妇)+1.0218(ECV 时横位或斜位)-0.5113(前胎盘)。创建了该方程的交互式版本,并可在 www.ecvcalculator.com 上访问。
创建了一种预测 ECV 成功概率的模型,并进行了内部验证。该模型纳入了 ECV 前已知的易于获得和客观的患者因素,可用于 ECV 的决策制定和患者咨询。