α-硫辛酸对糖尿病斑马鱼模型毛细胞损伤的保护作用
Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model.
作者信息
Kim Eunmi, Lee Dong-Won, Park Hae-Chul, Kim Dong Hwee
机构信息
Department of Biomedical Sciences, College of Medicine, Korea University, Ansan 15355, Republic of Korea.
Department of Physical Medicine and Rehabilitation, College of Medicine, Korea University, Ansan 15355, Republic of Korea.
出版信息
Mol Genet Metab Rep. 2021 Jul 21;28:100783. doi: 10.1016/j.ymgmr.2021.100783. eCollection 2021 Sep.
Hearing impairment is one of the complications in diabetes mellitus; however, there are very few therapeutic studies on it. In this study, we investigated the protective effect of alpha-lipoic acid (ALA) on hearing loss in diabetic transgenic zebrafish and confirmed that ALA protects the loss of hair cells (HCs) caused by hyperglycemia. The data indicated that ALA has a protective effect on the damage to HCs in diabetic zebrafish.
听力障碍是糖尿病的并发症之一；然而，针对它的治疗研究非常少。在本研究中，我们调查了α-硫辛酸（ALA）对糖尿病转基因斑马鱼听力损失的保护作用，并证实ALA可保护高血糖引起的毛细胞（HCs）损失。数据表明，ALA对糖尿病斑马鱼的HCs损伤具有保护作用。
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