Red Blood Cell Research Group, Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zürich, CH-8057 Zurich, Switzerland.
Biochemistry Department, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91905, Israel.
Biomolecules. 2021 Jul 5;11(7):992. doi: 10.3390/biom11070992.
Red blood cell (RBC) transfusion is one of the most common therapeutic procedures in modern medicine. Although frequently lifesaving, it often has deleterious side effects. RBC quality is one of the critical factors for transfusion efficacy and safety. The role of various factors in the cells' ability to maintain their functionality during storage is widely discussed in professional literature. Thus, the extra- and intracellular factors inducing an accelerated RBC aging need to be identified and therapeutically modified. Despite the extensively studied in vivo effect of chronic hyperglycemia on RBC hemodynamic and metabolic properties, as well as on their lifespan, only limited attention has been directed at the high sugar concentration in RBCs storage media, a possible cause of damage to red blood cells. This mini-review aims to compare the biophysical and biochemical changes observed in the red blood cells during cold storage and in patients with non-insulin-dependent diabetes mellitus (NIDDM). Given the well-described corresponding RBC alterations in NIDDM and during cold storage, we may regard the stored (especially long-stored) RBCs as "quasi-diabetic". Keeping in mind that these RBC modifications may be crucial for the initial steps of microvascular pathogenesis, suitable preventive care for the transfused patients should be considered. We hope that our hypothesis will stimulate targeted experimental research to establish a relationship between a high sugar concentration in a storage medium and a deterioration in cells' functional properties during storage.
红细胞（RBC）输血是现代医学中最常见的治疗方法之一。尽管经常是救生的，但它经常有有害的副作用。RBC 质量是输血疗效和安全性的关键因素之一。专业文献广泛讨论了各种因素对细胞在储存过程中维持其功能的能力的影响。因此，需要识别并治疗性地改变导致 RBC 加速老化的细胞内外因素。尽管慢性高血糖对 RBC 血液动力学和代谢特性以及寿命的体内影响已被广泛研究，但对于 RBC 储存介质中高糖浓度可能导致红细胞损伤的问题，仅受到了有限的关注。本篇迷你综述旨在比较冷储存期间和非胰岛素依赖型糖尿病（NIDDM）患者中观察到的 RBC 的生物物理和生化变化。鉴于 NIDDM 和冷储存期间 RBC 发生的相应改变已被充分描述，我们可以将储存的（尤其是长期储存的）RBC 视为“类糖尿病”。鉴于这些 RBC 改变可能对微血管发病机制的初始步骤至关重要，应该考虑为接受输血的患者提供适当的预防性护理。我们希望我们的假设将激发有针对性的实验研究，以建立储存介质中高糖浓度与储存过程中细胞功能特性恶化之间的关系。
