蓝光照射对人脐静脉内皮细胞的双相效应。
Biphasic Effects of Blue Light Irradiation on Human Umbilical Vein Endothelial Cells.
作者信息
Kan Kejia, Mu Yifei, Bouschbacher Marielle, Sticht Carsten, Kuch Natalia, Sigl Martin, Rahbari Nuh, Gretz Norbert, Pallavi Prama, Keese Michael
机构信息
Department of Vascular Surgery, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
European Center of Angioscience ECAS, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
出版信息
Biomedicines. 2021 Jul 16;9(7):829. doi: 10.3390/biomedicines9070829.
Blue light regulates biological function in various cells, such as proliferation, oxidative stress, and cell death. We employed blue light illumination on human umbilical vein endothelial cells utilizing a LED device at 453 nm wavelength and revealed a novel biphasic response on human umbilical vein endothelial cells (HUVECs). The results showed that low fluence blue light irradiation promoted the fundamental cell activities, including cell viability, migration and angiogenesis by activating the angiogenic pathways such as the VEGF signaling pathway. In contrast, high fluence illumination caused the opposite effect on those activities by upregulating pro-apoptotic signaling cascades like ferroptosis, necroptosis and the p53 signaling pathways. Our results provide an underlying insight into photobiomodulation by blue light and may help to implement potential treatment strategies for treating angiogenesis-dependent diseases.
蓝光可调节多种细胞的生物学功能，如增殖、氧化应激和细胞死亡。我们使用波长为453nm的发光二极管（LED）装置对人脐静脉内皮细胞进行蓝光照射，并揭示了人脐静脉内皮细胞（HUVECs）的一种新的双相反应。结果表明，低通量蓝光照射通过激活血管生成途径（如VEGF信号通路）促进了基本的细胞活动，包括细胞活力、迁移和血管生成。相反，高通量照射通过上调促凋亡信号级联反应（如铁死亡、坏死性凋亡和p53信号通路）对这些活动产生相反的影响。我们的结果为蓝光光生物调节提供了潜在的见解，并可能有助于实施治疗血管生成依赖性疾病的潜在治疗策略。
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