神经行为生物标志物：脑电图的家庭聚会。
Neurobehavioral Biomarkers: An EEG Family Reunion.
机构信息
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland, U.S.A.
Department of Neurology and Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, U.S.A.
出版信息
J Clin Neurophysiol. 2022 Feb 1;39(2):129-134. doi: 10.1097/WNP.0000000000000836.
The field of clinical EEG has had an uneasy relationship with the use of this technology for clinical cognitive applications and often for good reason. However, apart from its clinical use, EEG has had a tradition as a major tool in cognitive psychology and cognitive neuroscience dating back at least to the 1960s. Based on accumulated knowledge from its research application, EEG-based biomarkers are beginning to see applications in clinical trials and may eventually enter clinical care. We address concerns surrounding quality control, the treatment of artifact, and normal variants and how developments in engineering, biomarker validation, and implementation science rigorously applied to these tools can lead to well-justified approaches.
临床脑电图领域与将该技术用于临床认知应用的关系一直不太融洽，而且往往是有充分理由的。然而，除了临床应用之外，脑电图作为认知心理学和认知神经科学的主要工具已有传统，可以追溯到至少 20 世纪 60 年代。基于其研究应用中积累的知识，基于脑电图的生物标志物开始在临床试验中得到应用，并最终可能进入临床护理。我们将讨论围绕质量控制、伪影处理以及正常变异的问题，以及工程学、生物标志物验证和实施科学方面的发展如何严格应用于这些工具，从而可以得出合理的方法。
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