Ren Xueling, Wang Shengshu, He Yan, Lian Junsong, Lu Qian, Gao Yanhong, Wang Yuling
Department of Respiratory, The Second Medical Center of Chinese PLA General Hospital, Beijing, China.
Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, The Second Medical Center of Chinese PLA General Hospital, Beijing, China.
Front Psychol. 2021 Jul 22;12:585597. doi: 10.3389/fpsyg.2021.585597. eCollection 2021.
Chronic lung diseases (CLDs) can reduce patients' quality of life. However, evidence for the relationship between CLD and occurrence with depressive symptoms remains unclear. This study aims to determine the associations between CLD and depressive symptoms incidence, using the data from the China Health and Retirement Longitudinal Study (CHARLS). CLD was identified via survey questionnaire and hospitalization. The follow-up survey was conducted in 2018 and depressive symptoms were assessed by the 10-item Center for Epidemiological Studies Depression Scale (CES-D-10). A total of 10,508 participants were studied with an average follow-up period of 3 years. A total of 2706 patients (25.8%) with newly diagnosed depressive symptoms were identified. The standardized incidence rate of depressive symptoms in baseline population with and without chronic pulmonary disease was 11.9/100 and 8.3/100 person-years, respectively. The Cox proportional risk model showed that CLD was a significant predictor of depressive symptoms (HR: 1.449, 95% CI: 1.235-1.700) after adjusting for covariates, and the HRs of depressive symptoms were higher in those participants with current smoking (HR: 1.761, 95% CI: 1.319-2.352), men (HR: 1.529, 95% CI: 1.236-1.892), living in rural areas (HR: 1.671, 95% CI: 1.229-2.272), with dyslipidemia (HR: 1.896, 95% CI: 1.180-3.045), and suffering from comorbidity (HR: 1.518, 95% CI: 1.104-2.087) at baseline survey. CLD was an independent risk factor of depressive symptoms in China. The mental health of CLD patients deserves more attention.
慢性肺部疾病（CLDs）会降低患者的生活质量。然而，CLD与抑郁症状发生之间关系的证据仍不明确。本研究旨在利用中国健康与养老追踪调查（CHARLS）的数据，确定CLD与抑郁症状发生率之间的关联。通过调查问卷和住院情况来确定CLD。2018年进行了随访调查，采用10项流行病学研究中心抑郁量表（CES-D-10）评估抑郁症状。共对10508名参与者进行了研究，平均随访期为3年。共识别出2706例（25.8%）新诊断出抑郁症状的患者。有慢性肺病和无慢性肺病的基线人群中抑郁症状的标准化发病率分别为11.9/100人年和8.3/100人年。Cox比例风险模型显示，在调整协变量后，CLD是抑郁症状的显著预测因素（HR：1.449，95%CI：1.235 - 1.700），并且在基线调查时，当前吸烟者（HR：1.761，95%CI：1.319 - 2.352）、男性（HR：1.529，95%CI：1.236 - 1.892）、居住在农村地区者（HR：1.671，95%CI：1.229 - 2.272）、患有血脂异常者（HR：1.896，95%CI：1.180 - 3.045）以及患有合并症者（HR：1.518，95%CI：1.104 - 2.087）中抑郁症状的HR更高。在中国，CLD是抑郁症状的独立危险因素。CLD患者的心理健康值得更多关注。
