氨基酸与肽。十八。Z-天冬氨酸（苄酯）-OH合成过程中的二肽形成。

Amino acids and peptides. XVIII. Dipeptide formation during the synthesis of Z-Asp(OBzl)-OH.

作者信息

Iguchi S, Kawasaki K, Okada Y

机构信息

Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.

出版信息

Int J Pept Protein Res. 1987 Nov;30(5):695-700. doi: 10.1111/j.1399-3011.1987.tb03382.x.

DOI:10.1111/j.1399-3011.1987.tb03382.x

PMID:3436707

Abstract

During the benzyloxycarbonylation of H-Asp(OBzl)-OH by the Schotten-Bauman reaction with benzyloxycarbonyl chloride in the presence of NaHCO3 or Na2CO3, besides Z-Asp(OBzl)-OH, Z-Asp(OBzl)-Asp(OBzl)-OH was formed as side product, although the extent of the dipeptide formation differed depending on the base used (10% and 20% respectively). It was found that melting point, rotation value and Rf values upon thin-layer chromatography of Z-Asp(OBzl)-Asp(OBzl)-OH were quite similar to those of Z-Asp(OBzl)-OH.

摘要

在用苄氧羰基氯通过肖滕-鲍曼反应对H-Asp(OBzl)-OH进行苄氧羰基化时，在碳酸氢钠或碳酸钠存在下，除了Z-Asp(OBzl)-OH外，还会形成Z-Asp(OBzl)-Asp(OBzl)-OH作为副产物，尽管二肽形成的程度因所用碱的不同而有所差异（分别为10%和20%）。研究发现，Z-Asp(OBzl)-Asp(OBzl)-OH的熔点、旋光值以及薄层色谱的Rf值与Z-Asp(OBzl)-OH的非常相似。