Independent Researcher, Potomac, MD, USA.
F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Psychiatr Clin North Am. 2021 Sep;44(3):443-458. doi: 10.1016/j.psc.2021.04.003. Epub 2021 Jul 7.
This article focuses on neuropsychiatric clinical expression and neuropathology associated with chronic traumatic encephalopathy (CTE), which is thought to develop years after traumatic brain injury. The incidence, prevalence, additional risk factors, and pathophysiology remain largely unknown. CTE is considered a tauopathy because the endogenous brain protein tau, in its hyperphosphorylated state (p-tau), defines the predominant neuropathological findings and may underlie aspects of cell toxicity, synapse and circuit dysfunction, and clinical signs and symptoms. We discuss pathophysiological mechanisms possibly affecting p-tau accumulation. Finally, we interweave how clinical features and neuroanatomical sites associated with CTE potentially intersect with posttraumatic stress disorder.
本文重点介绍与慢性创伤性脑病（CTE）相关的神经精神临床特征和神经病理学，据认为该病是在创伤性脑损伤多年后发展起来的。该病的发病率、患病率、其他危险因素和发病机制在很大程度上仍不清楚。CTE 被认为是一种 tau 病，因为内源性脑蛋白 tau 在其过度磷酸化状态（p-tau）下定义了主要的神经病理学发现，并可能是细胞毒性、突触和回路功能障碍以及临床体征和症状的基础。我们讨论了可能影响 p-tau 积累的病理生理机制。最后，我们交织了与 CTE 相关的临床特征和神经解剖部位如何与创伤后应激障碍（PTSD）相互作用。
