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免疫性血小板减少症,新型冠状病毒肺炎患者的严重血液学后果:一例病例报告。

Immune thrombocytopenia, severe hematological consequence in a patient with COVID-19: A case report.

作者信息

Badulescu Oana-Viola, Popescu Diana, Ciocoiu Manuela, Rezus Ciprian

机构信息

Department of Pathophysiology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.

Department of Internal Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.

出版信息

Exp Ther Med. 2021 Sep;22(3):1043. doi: 10.3892/etm.2021.10475. Epub 2021 Jul 21.

Abstract

Since the first appearance of coronavirus disease 2019 (COVID-19), multiple studies have focused on this novel coronavirus. Within a few months, the clinical and paraclinical manifestations and the mechanisms by which these changes are induced were elaborated. Clinically, the virus mainly causes the common cold, but can also result in severe or fatal pneumonia/acute respiratory syndrome. Regarding the biological changes, similar to any other virus, it can lead to a reduced lymphocyte count. The second most common change is represented by a reduced thrombocyte count. Furthermore, most patients have blood clotting abnormalities, inflammatory syndrome, raised D-dimer and lactate dehydrogenase levels. Detection of immune thrombocytopenia in asymptomatic patients who tested positive for COVID-19 justifies the need to perform differential diagnosis and testing for COVID-19. Typically, patients with severe forms of COVID-19 develop mild thrombocytopenia, while severe thrombocytopenia is rarely reported. The aim of this case report was to present the situation in which one asymptomatic patient who tested positive for COVID-19 developed severe immune thrombocytopenia.

摘要

自2019年冠状病毒病(COVID-19)首次出现以来,多项研究聚焦于这种新型冠状病毒。在几个月内,其临床和亚临床症状以及这些变化产生的机制就得到了详细阐述。临床上,该病毒主要引起普通感冒,但也可导致严重或致命的肺炎/急性呼吸综合征。关于生物学变化,与任何其他病毒一样,它可导致淋巴细胞计数减少。第二常见的变化表现为血小板计数减少。此外,大多数患者存在凝血异常、炎症综合征、D-二聚体和乳酸脱氢酶水平升高。在COVID-19检测呈阳性的无症状患者中检测到免疫性血小板减少症,这证明有必要对COVID-19进行鉴别诊断和检测。通常,COVID-19重症患者会出现轻度血小板减少,而严重血小板减少的报告很少。本病例报告的目的是呈现一名COVID-19检测呈阳性的无症状患者出现严重免疫性血小板减少症的情况。

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