Takata M, Tomomune N, Nagahama T
Department of Physiology, School of Dentistry, Tokushima University, Japan.
Neuroscience. 1987 Nov;23(2):625-30. doi: 10.1016/0306-4522(87)90080-7.
The suppression of lingually or cortically induced postsynaptic potentials produced by conditioning stimulation of the cerebral cortex or the lingual nerve was studied in cat hypoglossal motoneurons. We have demonstrated that lingually or cortically induced inhibitory postsynaptic potentials were effectively suppressed by a conditioning stimulus of the cerebral cortex or the lingual nerve. In hypoglossal motoneurons after blocking inhibitory postsynaptic potentials by the administration of strychnine, lingually induced excitatory postsynaptic potentials and spikes were effectively suppressed by cortical stimulation. Whereas, a conditioning stimulus of the lingual nerve suppressed only a long-latency excitatory postsynaptic potential evoked by a test stimulus of the cerebral cortex, while a short-latency excitatory postsynaptic potential was unaffected. Picrotoxin and bicuculline appeared to act by reducing the suppression of lingually induced excitatory postsynaptic potentials produced by cortical conditioning stimulation.
在猫的舌下运动神经元中，研究了通过对大脑皮层或舌神经进行条件刺激来抑制由舌部或皮层诱导产生的突触后电位。我们已经证明，舌部或皮层诱导的抑制性突触后电位可被大脑皮层或舌神经的条件刺激有效抑制。在用士的宁阻断抑制性突触后电位后，在舌下运动神经元中，皮层刺激可有效抑制舌部诱导的兴奋性突触后电位和锋电位。然而，舌神经的条件刺激仅抑制由大脑皮层测试刺激诱发的长潜伏期兴奋性突触后电位，而短潜伏期兴奋性突触后电位不受影响。印防己毒素和荷包牡丹碱似乎是通过减少皮层条件刺激对舌部诱导的兴奋性突触后电位的抑制作用来发挥作用的。
